Synthesis of Methyl 4-Aryl-4-oxo-2-{4-[(1,3-thiazol-2-yl)-sulfamoyl]phenylamino}but-2-enoates and Their Reactions with Ninhydrin

Research output: Contribution to journal › Article › peer-review

Department of Electrochemistry

DOI

https://doi.org/10.1134/S107042801905004X
Final published version

V. L. Gein
O. V. Bobrovskaya
A. A. Russkikh
M. V. Dmitriev
A. N. Yankin

The reaction of methyl aroylpyruvates with 2-(4-aminobenzenesulfonamido)thiazole (norsulfazole) in acetic acid-ethanol (1: 1) afforded methyl (2Z)-4-aryl-4-oxo-2-{4-[(1,3-thiazol-2-yl)sulfamoyl]phenyl-amino} but-2-enoates which reacted with ninhydrin in glacial acetic acid to give 4-aroyl-3-{4-[(1,3-thiazol-2-yl)-sulfamoyl]phenylamino} spiro[2,5-dihydrofuran-5,2′-indane]-2,1′,3′-triones.

Original language	English
Pages (from-to)	602-607
Number of pages	6
Journal	Russian Journal of Organic Chemistry
Volume	55
Issue number	5
DOIs	https://doi.org/10.1134/S107042801905004X
State	Published - 1 May 2019

Research areas

2-(4-aminobenzenesulfonamido)thiazole (norsulfazole), 4-aroyl-3-{4-[(1,3-thiazol-2-yl)sulfamoyl]-phe-nylamino} spiro[2,5-dihydrofuran-5,2′-indane]-2,1′,3′-triones, synthesis, methyl (2Z)-4-aryl-4-oxo-2-{4-[(1,3-thiazol-2-yl)sulfamoyl]phenylamino} but-2-enoates, ninhydrin, 3-thiazol-2-yl)sulfamoyl]-phe-nylamino} spiro[2, synthesis, 2 '-indane]-2, ACIDS, methyl (2Z)-4-aryl-4-oxo-2-{4-[(1, 5-dihydrofuran-5, OXALYL DERIVATIVES, KETONES, 3 '-triones, REACTION-KINETICS, ESTERS, 1 ', CHEMISTRY, 3-thiazol-2-yl)sulfamoyl]phenylamino} but-2-enoates, 4-aroyl-3-{4-[(1

Scopus subject areas

Organic Chemistry

ID: 45307136