A four-step approach to 2-aryl-2H-tetrazole-5-carboxamides bearing GPCR-focused N-substituted piperazine residues involves ‘SAFE’ diazotransfer onto 1-(piperazin-1-yl)butane-1,3-diones followed by [3+2] cycloaddition of arenediazonium cations at the intermediate ααα-diazo acetamides. The compounds prepared are intended for photoaffinity labeling of aminergic G-protein coupled receptors.

Original languageEnglish
Pages (from-to)604-605
Number of pages2
JournalMendeleev Communications
Volume32
Issue number5
Early online dateOct 2022
DOIs
StatePublished - 2022

    Scopus subject areas

  • Chemistry(all)

    Research areas

  • GPCR privileged ligands, photoaffinity labeling, silver(t) catalysis, tetrazoles, [3+2] cycloaddition, α-diazo acetamides

ID: 100361291