TY - JOUR

T1 - Synthesis and Study of Zeolites Modified by Silver Nanoparticles and Clusters

T2 - Biological Activity

AU - Golubeva, O. Yu

AU - Ul’yanova, N. Yu

AU - Zharkova, M. S.

AU - Shamova, O. V.

PY - 2018/11/1

Y1 - 2018/11/1

N2 - Abstract: The biological activity of zeolites with Rho, Beta and paulingite structures modified with silver nanoparticles and clusters of 3 and 6 wt % is studied. The antimicrobial activity is studied with respect to gram-negative bacteria Escherichia coli ML35p and gram-positive bacteria MRSA ATCC 33591 (Staphylococcus aureus, antibiotic resistant strain) by serial dilutions in a liquid nutrient medium. The effect of drugs on the viability of eukaryotic cells is examined using a marker of the metabolic activity of resazurin cells (Alamar Blue). In the experiments, the cells of transplanted ascites carcinoma of the Ehrlich zmouse were used, as well as the normal, untransformed peritoneal macrophages of mice. It is shown that the activity of modified zeolites is determined by the form of silver present in them (nanoparticles, clusters), by its localization (intracrystalline cavities or outer surface of the framework), and by the structural type of the zeolite matrix.

AB - Abstract: The biological activity of zeolites with Rho, Beta and paulingite structures modified with silver nanoparticles and clusters of 3 and 6 wt % is studied. The antimicrobial activity is studied with respect to gram-negative bacteria Escherichia coli ML35p and gram-positive bacteria MRSA ATCC 33591 (Staphylococcus aureus, antibiotic resistant strain) by serial dilutions in a liquid nutrient medium. The effect of drugs on the viability of eukaryotic cells is examined using a marker of the metabolic activity of resazurin cells (Alamar Blue). In the experiments, the cells of transplanted ascites carcinoma of the Ehrlich zmouse were used, as well as the normal, untransformed peritoneal macrophages of mice. It is shown that the activity of modified zeolites is determined by the form of silver present in them (nanoparticles, clusters), by its localization (intracrystalline cavities or outer surface of the framework), and by the structural type of the zeolite matrix.

KW - antimicrobial activity

KW - antitumor activity

KW - clusters

KW - silver nanoparticles

KW - zeolites

UR - http://www.scopus.com/inward/record.url?scp=85062625945&partnerID=8YFLogxK

U2 - 10.1134/S108765961806007X

DO - 10.1134/S108765961806007X

M3 - Article

AN - SCOPUS:85062625945

VL - 44

SP - 586

EP - 590

JO - Glass Physics and Chemistry

JF - Glass Physics and Chemistry

SN - 1087-6596

IS - 6

ER -