Abstract: The biological activity of zeolites with Rho, Beta and paulingite structures modified with silver nanoparticles and clusters of 3 and 6 wt % is studied. The antimicrobial activity is studied with respect to gram-negative bacteria Escherichia coli ML35p and gram-positive bacteria MRSA ATCC 33591 (Staphylococcus aureus, antibiotic resistant strain) by serial dilutions in a liquid nutrient medium. The effect of drugs on the viability of eukaryotic cells is examined using a marker of the metabolic activity of resazurin cells (Alamar Blue). In the experiments, the cells of transplanted ascites carcinoma of the Ehrlich zmouse were used, as well as the normal, untransformed peritoneal macrophages of mice. It is shown that the activity of modified zeolites is determined by the form of silver present in them (nanoparticles, clusters), by its localization (intracrystalline cavities or outer surface of the framework), and by the structural type of the zeolite matrix.