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Synthesis and In vitro Study of Cytotoxic Activity of New Tetrazole-Containing 2,4-Diamino-1,3,5-triazine Derivatives. / Mikolaichuk, O. V.; Protas, A. V.; Popova, E. A.; Molchanov, O. E.; Maistrenko, D. N.; Ostrovskii, V. A.; Pavlyukova, Yu N.; Sharoyko, V. V.; Semenov, K. N.

In: Russian Journal of General Chemistry, Vol. 92, No. 9, 01.09.2022, p. 1621-1628.

Research output: Contribution to journal › Article › peer-review

Harvard

Mikolaichuk, OV, Protas, AV, Popova, EA, Molchanov, OE, Maistrenko, DN, Ostrovskii, VA, Pavlyukova, YN, Sharoyko, VV & Semenov, KN 2022, 'Synthesis and In vitro Study of Cytotoxic Activity of New Tetrazole-Containing 2,4-Diamino-1,3,5-triazine Derivatives', Russian Journal of General Chemistry, vol. 92, no. 9, pp. 1621-1628. https://doi.org/10.1134/s1070363222090055

APA

Mikolaichuk, O. V., Protas, A. V., Popova, E. A., Molchanov, O. E., Maistrenko, D. N., Ostrovskii, V. A., Pavlyukova, Y. N., Sharoyko, V. V., & Semenov, K. N. (2022). Synthesis and In vitro Study of Cytotoxic Activity of New Tetrazole-Containing 2,4-Diamino-1,3,5-triazine Derivatives. Russian Journal of General Chemistry, 92(9), 1621-1628. https://doi.org/10.1134/s1070363222090055

Vancouver

Mikolaichuk OV, Protas AV, Popova EA, Molchanov OE, Maistrenko DN, Ostrovskii VA et al. Synthesis and In vitro Study of Cytotoxic Activity of New Tetrazole-Containing 2,4-Diamino-1,3,5-triazine Derivatives. Russian Journal of General Chemistry. 2022 Sep 1;92(9):1621-1628. https://doi.org/10.1134/s1070363222090055

Author

Mikolaichuk, O. V. ; Protas, A. V. ; Popova, E. A. ; Molchanov, O. E. ; Maistrenko, D. N. ; Ostrovskii, V. A. ; Pavlyukova, Yu N. ; Sharoyko, V. V. ; Semenov, K. N. / Synthesis and In vitro Study of Cytotoxic Activity of New Tetrazole-Containing 2,4-Diamino-1,3,5-triazine Derivatives. In: Russian Journal of General Chemistry. 2022 ; Vol. 92, No. 9. pp. 1621-1628.

BibTeX

@article{580beb1ed9d549c396904d59c8ec7a75,
title = "Synthesis and In vitro Study of Cytotoxic Activity of New Tetrazole-Containing 2,4-Diamino-1,3,5-triazine Derivatives",
abstract = "Abstract: New tetrazole-containing derivatives of 2,4-diamino-1,3,5-triazine were synthesized. The cytotoxic activity of the obtained compounds against Huh-7 and HeLa tumor cell lines was studied by the MTT test. The most significant antitumor activity was shown by 1,3,5-triazines containing a 5-phenyltetrazol-2-ylacetohydrazide fragment. The resulting compounds showed practically no cytotoxic effect on non-tumor cells of the human embryonic kidney line HEK293.",
keywords = "1,3,5-triazines, cytotoxic activity, MTT test, tetrazoles",
author = "Mikolaichuk, {O. V.} and Protas, {A. V.} and Popova, {E. A.} and Molchanov, {O. E.} and Maistrenko, {D. N.} and Ostrovskii, {V. A.} and Pavlyukova, {Yu N.} and Sharoyko, {V. V.} and Semenov, {K. N.}",
note = "Mikolaichuk, O.V., Protas, A.V., Popova, E.A. et al. Synthesis and In vitro Study of Cytotoxic Activity of New Tetrazole-Containing 2,4-Diamino-1,3,5-triazine Derivatives. Russ J Gen Chem 92, 1621–1628 (2022). https://doi.org/10.1134/S1070363222090055",
year = "2022",
month = sep,
day = "1",
doi = "10.1134/s1070363222090055",
language = "English",
volume = "92",
pages = "1621--1628",
journal = "Russian Journal of General Chemistry",
issn = "1070-3632",
publisher = "МАИК {"}Наука/Интерпериодика{"}",
number = "9",

}

RIS

TY - JOUR

T1 - Synthesis and In vitro Study of Cytotoxic Activity of New Tetrazole-Containing 2,4-Diamino-1,3,5-triazine Derivatives

AU - Mikolaichuk, O. V.

AU - Protas, A. V.

AU - Popova, E. A.

AU - Molchanov, O. E.

AU - Maistrenko, D. N.

AU - Ostrovskii, V. A.

AU - Pavlyukova, Yu N.

AU - Sharoyko, V. V.

AU - Semenov, K. N.

N1 - Mikolaichuk, O.V., Protas, A.V., Popova, E.A. et al. Synthesis and In vitro Study of Cytotoxic Activity of New Tetrazole-Containing 2,4-Diamino-1,3,5-triazine Derivatives. Russ J Gen Chem 92, 1621–1628 (2022). https://doi.org/10.1134/S1070363222090055

PY - 2022/9/1

Y1 - 2022/9/1

N2 - Abstract: New tetrazole-containing derivatives of 2,4-diamino-1,3,5-triazine were synthesized. The cytotoxic activity of the obtained compounds against Huh-7 and HeLa tumor cell lines was studied by the MTT test. The most significant antitumor activity was shown by 1,3,5-triazines containing a 5-phenyltetrazol-2-ylacetohydrazide fragment. The resulting compounds showed practically no cytotoxic effect on non-tumor cells of the human embryonic kidney line HEK293.

AB - Abstract: New tetrazole-containing derivatives of 2,4-diamino-1,3,5-triazine were synthesized. The cytotoxic activity of the obtained compounds against Huh-7 and HeLa tumor cell lines was studied by the MTT test. The most significant antitumor activity was shown by 1,3,5-triazines containing a 5-phenyltetrazol-2-ylacetohydrazide fragment. The resulting compounds showed practically no cytotoxic effect on non-tumor cells of the human embryonic kidney line HEK293.

KW - 1,3,5-triazines

KW - cytotoxic activity

KW - MTT test

KW - tetrazoles

UR - http://www.scopus.com/inward/record.url?scp=85140260513&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/f1cb30b4-f0fc-34c9-aedb-29a222a5faa7/

U2 - 10.1134/s1070363222090055

DO - 10.1134/s1070363222090055

M3 - Article

AN - SCOPUS:85140260513

VL - 92

SP - 1621

EP - 1628

JO - Russian Journal of General Chemistry

JF - Russian Journal of General Chemistry

SN - 1070-3632

IS - 9

ER -

ID: 100131646