Substantiation of the model for calculating the individual dose of cytostatics using CT volumetry for isolated lung chemioperfusion with metastasectomy. / Levchenko, E. V.; Kalinin, P. S.; Senchik, K. Yu; Wen, Zhang; Tin, Van; Mamontov, O. Yu; Mishchenko, A. V.; Shevkunov, L. N.; Ulianchenko, Ya A.; Levchenko, N. E.; Gumbatova, E. D.; Dubinina, T. V.
In: Voprosy Onkologii, Vol. 64, No. 3, 2018, p. 319-324.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Substantiation of the model for calculating the individual dose of cytostatics using CT volumetry for isolated lung chemioperfusion with metastasectomy
AU - Levchenko, E. V.
AU - Kalinin, P. S.
AU - Senchik, K. Yu
AU - Wen, Zhang
AU - Tin, Van
AU - Mamontov, O. Yu
AU - Mishchenko, A. V.
AU - Shevkunov, L. N.
AU - Ulianchenko, Ya A.
AU - Levchenko, N. E.
AU - Gumbatova, E. D.
AU - Dubinina, T. V.
N1 - Publisher Copyright: © 2018 Izdatel'stvo Meditsina. All rights reserved.
PY - 2018
Y1 - 2018
N2 - In order to create conditions for increasing the effectiveness of treatment of patients with metastatic lung disease a new method for calculating the dose of antitumor drug for performing isolated chemo-perfusion of the lung with metastasectomy taking into account the anatomical features of patients and previous operations on the lung was developed. The study consisted of three stages. As a result of the first stage of the study the effectiveness of the software package was measured in the volume of lung patients based on the presence of a strong positive correlation between the volumes of left lungs (Rs = 0.91, p <0.001), right lungs (Rs = 0.94, p <0.001) during the primary and repeated CT chest. As a result of the second stage of the study a weakly positive relationship was found between the volume of right lungs and the surface area of patients' bodies (Rs = 0.32-0.40, p <0.001) and a weakly positive relationship between the volume of left lungs and the surface area of the patients' bodies (Rs = 0, 32-0,40, p <0,001), which confirms the inexpediency of dosing an antitumor drug for lung chemo-perfusion based on the body surface area of a patient. As a result of the third stage of the study a method for calculating the dose of melphalan and cisplatin for performing lung chemo-perfusion based on CT lung volumetry was developed.
AB - In order to create conditions for increasing the effectiveness of treatment of patients with metastatic lung disease a new method for calculating the dose of antitumor drug for performing isolated chemo-perfusion of the lung with metastasectomy taking into account the anatomical features of patients and previous operations on the lung was developed. The study consisted of three stages. As a result of the first stage of the study the effectiveness of the software package was measured in the volume of lung patients based on the presence of a strong positive correlation between the volumes of left lungs (Rs = 0.91, p <0.001), right lungs (Rs = 0.94, p <0.001) during the primary and repeated CT chest. As a result of the second stage of the study a weakly positive relationship was found between the volume of right lungs and the surface area of patients' bodies (Rs = 0.32-0.40, p <0.001) and a weakly positive relationship between the volume of left lungs and the surface area of the patients' bodies (Rs = 0, 32-0,40, p <0,001), which confirms the inexpediency of dosing an antitumor drug for lung chemo-perfusion based on the body surface area of a patient. As a result of the third stage of the study a method for calculating the dose of melphalan and cisplatin for performing lung chemo-perfusion based on CT lung volumetry was developed.
KW - Cisplatin
KW - CT volumetry
KW - Isolated lung chemoprefusion
KW - Melphalan
KW - Metastatic lung lesion
UR - http://www.scopus.com/inward/record.url?scp=85052728382&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:85052728382
VL - 64
SP - 319
EP - 324
JO - Вопросы онкологии
JF - Вопросы онкологии
SN - 0507-3758
IS - 3
ER -
ID: 88345247