In order to create conditions for increasing the effectiveness of treatment of patients with metastatic lung disease a new method for calculating the dose of antitumor drug for performing isolated chemo-perfusion of the lung with metastasectomy taking into account the anatomical features of patients and previous operations on the lung was developed. The study consisted of three stages. As a result of the first stage of the study the effectiveness of the software package was measured in the volume of lung patients based on the presence of a strong positive correlation between the volumes of left lungs (Rs = 0.91, p <0.001), right lungs (Rs = 0.94, p <0.001) during the primary and repeated CT chest. As a result of the second stage of the study a weakly positive relationship was found between the volume of right lungs and the surface area of patients' bodies (Rs = 0.32-0.40, p <0.001) and a weakly positive relationship between the volume of left lungs and the surface area of the patients' bodies (Rs = 0, 32-0,40, p <0,001), which confirms the inexpediency of dosing an antitumor drug for lung chemo-perfusion based on the body surface area of a patient. As a result of the third stage of the study a method for calculating the dose of melphalan and cisplatin for performing lung chemo-perfusion based on CT lung volumetry was developed.