DNA interaction with disulfophthalocyanine of cobalt (CodSPC) was studied by UVVIS spectrophotometry and low gradient viscometry. The thermal denaturation of DNA in complexes with CodSPC was compared with free DNA denaturation. The small increase in melting temperature indicates that the secondary structure of DNA in complexes is stable. As a results of experimental research the external binding of CodSPC to DNA was determined. The only one type of binding is accompanied by stacking of heterocycles at high concentrations of CodSPC. An increase in viscosity of DNA solutions with the growth of CodSPC concentration can be explained by intermolecular DNA contacts via CodSPC.

Original languageEnglish
Title of host publicationINTERNATIONAL CONFERENCE PHYSICA.SPB
EditorsNS Averkiev, SA Poniaev, GS Sokolovskii
PublisherIOP Publishing Ltd.
Number of pages6
DOIs
StatePublished - 18 Jun 2018
EventInternational Conference PhysicA.SPb 2017 - Санкт-Петербург, Russian Federation
Duration: 24 Oct 201726 Oct 2017
http://physica.spb.ru/archive/physica2017/

Publication series

NameJournal of Physics: Conference Series
PublisherIOP Publishing Ltd.
Volume1038
ISSN (Print)1742-6588

Conference

ConferenceInternational Conference PhysicA.SPb 2017
Abbreviated titlePhysica.SPb 2017
Country/TerritoryRussian Federation
CityСанкт-Петербург
Period24/10/1726/10/17
Internet address

    Scopus subject areas

  • Physics and Astronomy(all)

    Research areas

  • BINDING, PHTHALOCYANINE

ID: 73398702