The present status of tests of QED with highly charged ions is reviewed. The theoretical predictions for the Lamb shift and the transition energies are compared with available experimental data. Recent achievements in studies of the hyperfine splitting and the g-factor isotope shift with highly charged ions are reported. Special attention is paid to tests of QED within and beyond the Furry picture at strong-coupling regime. Prospects for tests of QED at supercritical fields that can be created in low-energy heavy-ion collisions are discussed as well.