Statins and autoimmune diseases. / Gurevich, Victor S.; Shovman, Ora; Slutzky, Liat; Meroni, Pier Luigi; Shoenfeld, Yehuda.
In: Autoimmunity Reviews, Vol. 4, No. 3, 03.2005, p. 123-129.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Statins and autoimmune diseases
AU - Gurevich, Victor S.
AU - Shovman, Ora
AU - Slutzky, Liat
AU - Meroni, Pier Luigi
AU - Shoenfeld, Yehuda
PY - 2005/3
Y1 - 2005/3
N2 - Inhibitors of 3-hydroxy-3methylglytaryl coenzyme A (HMG-CoA) reductase or statins are effective lipid lowering drugswidely used in cardiovascular disease. In the recent years, pleotropic effects of statins have been reported, which include anti-inflammatory and immunomodulatory properties. This review discusses the anti-inflammatory and immunomodulatory roles of statins and their possible use for the treatment of other inflammatory diseases or conditions with the involvement of the immune system. (c) 2004 Elsevier B.V. All rights reserved.
AB - Inhibitors of 3-hydroxy-3methylglytaryl coenzyme A (HMG-CoA) reductase or statins are effective lipid lowering drugswidely used in cardiovascular disease. In the recent years, pleotropic effects of statins have been reported, which include anti-inflammatory and immunomodulatory properties. This review discusses the anti-inflammatory and immunomodulatory roles of statins and their possible use for the treatment of other inflammatory diseases or conditions with the involvement of the immune system. (c) 2004 Elsevier B.V. All rights reserved.
KW - statins
KW - atherosclerosis
KW - anti-inflammatory
KW - immunomodulatory
KW - anti-phospholipid syndrome
KW - inflammatory arthritis
KW - neuroinflammatory diseases
KW - SLE
KW - HMG-COA REDUCTASE
KW - HUMAN ATHEROSCLEROTIC PLAQUES
KW - MULTIPLE-SCLEROSIS
KW - TISSUE FACTOR
KW - MATRIX METALLOPROTEINASES
KW - ANTIINFLAMMATORY ROLE
KW - LUPUS-ERYTHEMATOSUS
KW - CELL-PROLIFERATION
KW - IN-VITRO
KW - SIMVASTATIN
UR - http://www.scopus.com/inward/record.url?scp=16844371792&partnerID=8YFLogxK
U2 - 10.1016/j.autrev.2004.08.037
DO - 10.1016/j.autrev.2004.08.037
M3 - статья
C2 - 15823497
VL - 4
SP - 123
EP - 129
JO - Autoimmunity Reviews
JF - Autoimmunity Reviews
SN - 1568-9972
IS - 3
ER -
ID: 5459775