Statins and autoimmune diseases

Research output: Contribution to journal › Article › peer-review

DOI

https://doi.org/10.1016/j.autrev.2004.08.037
Final published version

Victor S. Gurevich
Ora Shovman
Liat Slutzky
Pier Luigi Meroni
Yehuda Shoenfeld

Inhibitors of 3-hydroxy-3methylglytaryl coenzyme A (HMG-CoA) reductase or statins are effective lipid lowering drugswidely used in cardiovascular disease. In the recent years, pleotropic effects of statins have been reported, which include anti-inflammatory and immunomodulatory properties. This review discusses the anti-inflammatory and immunomodulatory roles of statins and their possible use for the treatment of other inflammatory diseases or conditions with the involvement of the immune system. (c) 2004 Elsevier B.V. All rights reserved.

Original language	English
Pages (from-to)	123-129
Number of pages	7
Journal	Autoimmunity Reviews
Volume	4
Issue number	3
DOIs	https://doi.org/10.1016/j.autrev.2004.08.037
State	Published - Mar 2005

Scopus subject areas

Immunology and Allergy
Immunology

Research areas

statins, atherosclerosis, anti-inflammatory, immunomodulatory, anti-phospholipid syndrome, inflammatory arthritis, neuroinflammatory diseases, SLE, HMG-COA REDUCTASE, HUMAN ATHEROSCLEROTIC PLAQUES, MULTIPLE-SCLEROSIS, TISSUE FACTOR, MATRIX METALLOPROTEINASES, ANTIINFLAMMATORY ROLE, LUPUS-ERYTHEMATOSUS, CELL-PROLIFERATION, IN-VITRO, SIMVASTATIN

ID: 5459775