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Spirocyclic amino alcohol building blocks prepared via a Prins-type cyclization in aqueous sulfuric acid. / Lukin, Alexey; Bagnyukova, Darya; Kalinchenkova, Natalya; Zhurilo, Nikolay; Krasavin, Mikhail.

In: Tetrahedron Letters, Vol. 57, No. 30, 2016, p. 3311-3314.

Research output: Contribution to journal › Article › peer-review

Harvard

Lukin, A, Bagnyukova, D, Kalinchenkova, N, Zhurilo, N & Krasavin, M 2016, 'Spirocyclic amino alcohol building blocks prepared via a Prins-type cyclization in aqueous sulfuric acid', Tetrahedron Letters, vol. 57, no. 30, pp. 3311-3314. https://doi.org/10.106/j.tetlet.2016.06.054, https://doi.org/10.1016/j.tetlet.2016.06.054

APA

Lukin, A., Bagnyukova, D., Kalinchenkova, N., Zhurilo, N., & Krasavin, M. (2016). Spirocyclic amino alcohol building blocks prepared via a Prins-type cyclization in aqueous sulfuric acid. Tetrahedron Letters, 57(30), 3311-3314. https://doi.org/10.106/j.tetlet.2016.06.054, https://doi.org/10.1016/j.tetlet.2016.06.054

Vancouver

Lukin A, Bagnyukova D, Kalinchenkova N, Zhurilo N, Krasavin M. Spirocyclic amino alcohol building blocks prepared via a Prins-type cyclization in aqueous sulfuric acid. Tetrahedron Letters. 2016;57(30):3311-3314. https://doi.org/10.106/j.tetlet.2016.06.054, https://doi.org/10.1016/j.tetlet.2016.06.054

Author

Lukin, Alexey ; Bagnyukova, Darya ; Kalinchenkova, Natalya ; Zhurilo, Nikolay ; Krasavin, Mikhail. / Spirocyclic amino alcohol building blocks prepared via a Prins-type cyclization in aqueous sulfuric acid. In: Tetrahedron Letters. 2016 ; Vol. 57, No. 30. pp. 3311-3314.

BibTeX

@article{2d75f1a1eae4421190fecd90363c3703,
title = "Spirocyclic amino alcohol building blocks prepared via a Prins-type cyclization in aqueous sulfuric acid",
abstract = "A convenient Prins cyclization of various azacycloalkanones with homoallylic alcohol was achieved in aqueous sulfuric acid. The formal four-center, three-component reaction provides a facile and flexible entry into a range of spirocyclic amino alcohols which are valuable, {\textquoteleft}high-Fsp3{\textquoteright} motifs for drug design.",
keywords = "Amino alcohols, Bifunctional building blocks, High-Fscaffolds, Prins spirocylization, Privileged structures",
author = "Alexey Lukin and Darya Bagnyukova and Natalya Kalinchenkova and Nikolay Zhurilo and Mikhail Krasavin",
note = "Funding Information: This research was supported by the Russian Scientific Fund (project grant 14-50-00069 ). Publisher Copyright: {\textcopyright} 2016 Copyright: Copyright 2018 Elsevier B.V., All rights reserved.",
year = "2016",
doi = "10.106/j.tetlet.2016.06.054",
language = "English",
volume = "57",
pages = "3311--3314",
journal = "Tetrahedron Letters",
issn = "0040-4039",
publisher = "Elsevier",
number = "30",

}

RIS

TY - JOUR

T1 - Spirocyclic amino alcohol building blocks prepared via a Prins-type cyclization in aqueous sulfuric acid

AU - Lukin, Alexey

AU - Bagnyukova, Darya

AU - Kalinchenkova, Natalya

AU - Zhurilo, Nikolay

AU - Krasavin, Mikhail

N1 - Funding Information: This research was supported by the Russian Scientific Fund (project grant 14-50-00069 ). Publisher Copyright: © 2016 Copyright: Copyright 2018 Elsevier B.V., All rights reserved.

PY - 2016

Y1 - 2016

N2 - A convenient Prins cyclization of various azacycloalkanones with homoallylic alcohol was achieved in aqueous sulfuric acid. The formal four-center, three-component reaction provides a facile and flexible entry into a range of spirocyclic amino alcohols which are valuable, ‘high-Fsp3’ motifs for drug design.

AB - A convenient Prins cyclization of various azacycloalkanones with homoallylic alcohol was achieved in aqueous sulfuric acid. The formal four-center, three-component reaction provides a facile and flexible entry into a range of spirocyclic amino alcohols which are valuable, ‘high-Fsp3’ motifs for drug design.

KW - Amino alcohols

KW - Bifunctional building blocks

KW - High-Fscaffolds

KW - Prins spirocylization

KW - Privileged structures

UR - http://www.scopus.com/inward/record.url?scp=84976891128&partnerID=8YFLogxK

U2 - 10.106/j.tetlet.2016.06.054

DO - 10.106/j.tetlet.2016.06.054

M3 - Article

AN - SCOPUS:84976891128

VL - 57

SP - 3311

EP - 3314

JO - Tetrahedron Letters

JF - Tetrahedron Letters

SN - 0040-4039

IS - 30

ER -

ID: 9434297