A convenient Prins cyclization of various azacycloalkanones with homoallylic alcohol was achieved in aqueous sulfuric acid. The formal four-center, three-component reaction provides a facile and flexible entry into a range of spirocyclic amino alcohols which are valuable, ‘high-Fsp3’ motifs for drug design.
| Original language | English |
|---|---|
| Pages (from-to) | 3311-3314 |
| Number of pages | 4 |
| Journal | Tetrahedron Letters |
| Volume | 57 |
| Issue number | 30 |
| DOIs | |
| State | Published - 2016 |
ID: 9434297