TY - JOUR

T1 - Ruthenium-based microstructures modified by gold particles as composite electrode material for non-enzymatic epinephrine detection

AU - Панов, Максим Сергеевич

AU - Николаев, Дмитрий Михайлович

AU - Штыров, Андрей Андреевич

AU - Мерещенко, Андрей Сергеевич

AU - Васин, Андрей Владимирович

AU - Рязанцев, Михаил Николаевич

PY - 2024/11/1

Y1 - 2024/11/1

N2 - A simple and efficient technique for voltammetric enzymeless detection of epinephrine (EP) was proposed. In this technique, we applied hierarchical Ru-based electrode modified by Au nano- to micro-sized particles that was fabricated using laser-assisted synthesis. The cyclic voltammetry (CV) and differential pulse voltammetry (DPV) were employed to characterize electrochemical properties of the fabricated electrode material. For EP detection, we obtained two DPV calibration curves that were linear in the range of 0.05–5 μM and 5–500 μM. The highest sensitivity (45.0 μA μM−1 cm−2) and the lowest detection limit (6.4 nM) were observed for the first linear range, whereas the estimated sensitivity and limit of detection for the second linear range were 2.0 μA μM−1 cm−2 and 18.7 nM, respectively. We also demonstrated that the proposed technique can be used for selective EP determination in the presence of such common interfering analytes as ascorbic acid and dopamine. The results of this study can be potentially used for development of low-cost voltammetric sensor platforms for non-enzymatic epinephrine detection.

AB - A simple and efficient technique for voltammetric enzymeless detection of epinephrine (EP) was proposed. In this technique, we applied hierarchical Ru-based electrode modified by Au nano- to micro-sized particles that was fabricated using laser-assisted synthesis. The cyclic voltammetry (CV) and differential pulse voltammetry (DPV) were employed to characterize electrochemical properties of the fabricated electrode material. For EP detection, we obtained two DPV calibration curves that were linear in the range of 0.05–5 μM and 5–500 μM. The highest sensitivity (45.0 μA μM−1 cm−2) and the lowest detection limit (6.4 nM) were observed for the first linear range, whereas the estimated sensitivity and limit of detection for the second linear range were 2.0 μA μM−1 cm−2 and 18.7 nM, respectively. We also demonstrated that the proposed technique can be used for selective EP determination in the presence of such common interfering analytes as ascorbic acid and dopamine. The results of this study can be potentially used for development of low-cost voltammetric sensor platforms for non-enzymatic epinephrine detection.

KW - Epinephrine

KW - Gold

KW - Laser deposition

KW - Non-enzymatic sensing

KW - Ruthenium

KW - Voltammetric sensors

UR - https://www.mendeley.com/catalogue/d9d796e1-7a2e-3a18-9db6-c1959ad52215/

U2 - 10.1016/j.microc.2024.111507

DO - 10.1016/j.microc.2024.111507

M3 - Article

VL - 206

JO - Microchemical Journal

JF - Microchemical Journal

SN - 0026-265X

M1 - 111507

ER -