DOI

The molecular nature of the sup45 respiratory deficient omnipotent suppressor, and of three reversions to respiratory competence which removed the suppressor effect of the initial mutation, was examined. All reversions were caused by secondary sup45 mutations which indicates a direct connection between sup45 "respiratory" and "translational" functions. Computer analysis showed the local changes of Sup45 protein characteristics in the suppressor strain and revertants in comparison to the wild-type protein. The distribution of mutant sites in relation to evolutionary conserved, and tentatively functional, regions in the Sup45 protein is discussed.

Original languageEnglish
Pages (from-to)195-200
Number of pages6
JournalCurrent Genetics
Volume27
Issue number3
DOIs
StatePublished - Feb 1995

    Scopus subject areas

  • Genetics

    Research areas

  • Omnipotent suppression, Respiratory deficiency, Sup45 protein structure

ID: 84958624