Putative TAAR5 agonist alpha-NETA affects event-related potentials in oddball paradigm in awake mice.

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Putative TAAR5 agonist alpha-NETA affects event-related potentials in oddball paradigm in awake mice. / Aleksandrov, lAleksander A.; Knyazeva, Veronika M.; Volnova, Anna B.; Dmitrieva, Elena S.; Polyakova, Nadezhda V.

In: Brain Research Bulletin, Vol. 158, 05.2020, p. 116-121.

Research output: Contribution to journal › Article › peer-review

BibTeX

@article{e1e688728a394ce18428a85407a32990,

title = "Putative TAAR5 agonist alpha-NETA affects event-related potentials in oddball paradigm in awake mice.",

abstract = "Trace amines have been reported to be neuromodulators of monoaminergic systems. Trace amines receptor 5 (TAAR5) is expressed in several regions of mice central nervous system, such as amygdala, arcuate nucleus and ventromedial hypothalamus, but very limited information is available on its functional role. The purpose of this study is to examine the effect of TAAR5 agonist alpha-NETA on the generation of mismatch negativity (MMN) analogue in C57BL/6 mice. Event-related potentials have been recorded from awake mice in oddball paradigms before and after the alpha-NETA administration. Alpha-NETA has been found to decrease N40 MMN-like difference, which resulted from the increased response to standard stimuli. An opposite effect has been found for the P80 component: the amplitude increased in response both to standard and deviant stimuli. A significant increase in N40 peak latency after the alpha-NETA administration has been found. This may suggest a reduced speed of information processing similar to the increase in P50 and N100 components latencies in schizophrenia patients. These results provide new evidence for a role of TAAR5 in cognitive processes.",

keywords = "Trace amines associated receptors (TAARs), TAAR5, Alpha-NETA, Event-related potentials (ERPs), Mismatch negativity, Oddball paradigm, C57BL/6 mice, Schizophrenia endophenotypes, Event-Related potentials (ERPs)",

author = "Aleksandrov, {lAleksander A.} and Knyazeva, {Veronika M.} and Volnova, {Anna B.} and Dmitrieva, {Elena S.} and Polyakova, {Nadezhda V.}",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",

year = "2020",

month = may,

doi = "10.1016/j.brainresbull.2020.03.005",

language = "English",

volume = "158",

pages = "116--121",

journal = "Brain Research Bulletin",

issn = "0361-9230",

publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Putative TAAR5 agonist alpha-NETA affects event-related potentials in oddball paradigm in awake mice.

AU - Aleksandrov, lAleksander A.

AU - Knyazeva, Veronika M.

AU - Volnova, Anna B.

AU - Dmitrieva, Elena S.

AU - Polyakova, Nadezhda V.

PY - 2020/5

Y1 - 2020/5

N2 - Trace amines have been reported to be neuromodulators of monoaminergic systems. Trace amines receptor 5 (TAAR5) is expressed in several regions of mice central nervous system, such as amygdala, arcuate nucleus and ventromedial hypothalamus, but very limited information is available on its functional role. The purpose of this study is to examine the effect of TAAR5 agonist alpha-NETA on the generation of mismatch negativity (MMN) analogue in C57BL/6 mice. Event-related potentials have been recorded from awake mice in oddball paradigms before and after the alpha-NETA administration. Alpha-NETA has been found to decrease N40 MMN-like difference, which resulted from the increased response to standard stimuli. An opposite effect has been found for the P80 component: the amplitude increased in response both to standard and deviant stimuli. A significant increase in N40 peak latency after the alpha-NETA administration has been found. This may suggest a reduced speed of information processing similar to the increase in P50 and N100 components latencies in schizophrenia patients. These results provide new evidence for a role of TAAR5 in cognitive processes.

AB - Trace amines have been reported to be neuromodulators of monoaminergic systems. Trace amines receptor 5 (TAAR5) is expressed in several regions of mice central nervous system, such as amygdala, arcuate nucleus and ventromedial hypothalamus, but very limited information is available on its functional role. The purpose of this study is to examine the effect of TAAR5 agonist alpha-NETA on the generation of mismatch negativity (MMN) analogue in C57BL/6 mice. Event-related potentials have been recorded from awake mice in oddball paradigms before and after the alpha-NETA administration. Alpha-NETA has been found to decrease N40 MMN-like difference, which resulted from the increased response to standard stimuli. An opposite effect has been found for the P80 component: the amplitude increased in response both to standard and deviant stimuli. A significant increase in N40 peak latency after the alpha-NETA administration has been found. This may suggest a reduced speed of information processing similar to the increase in P50 and N100 components latencies in schizophrenia patients. These results provide new evidence for a role of TAAR5 in cognitive processes.

KW - Trace amines associated receptors (TAARs)

KW - TAAR5

KW - Alpha-NETA

KW - Event-related potentials (ERPs)

KW - Mismatch negativity

KW - Oddball paradigm

KW - C57BL/6 mice

KW - Schizophrenia endophenotypes

KW - Event-Related potentials (ERPs)

UR - http://www.scopus.com/inward/record.url?scp=85081203298&partnerID=8YFLogxK

U2 - 10.1016/j.brainresbull.2020.03.005

DO - 10.1016/j.brainresbull.2020.03.005

M3 - Article

VL - 158

SP - 116

EP - 121

JO - Brain Research Bulletin

JF - Brain Research Bulletin

SN - 0361-9230

ER -

ID: 52225242