Abstract: Some analytical problems, which are often considered incorrect for objective reasons, are considered. The main of these reasons is an anomalously large scatter of the initial data. It can be due to either the low reproducibility of the characteristics of substances, their quantities, analytical signal intensities, process conditions, etc., or variability due to differences in the nature of the objects themselves. In the latter case, the nature of data interpretation is influenced by analytical hypotheses adopted for their consideration. The tasks considered include variations in the component composition of developers for black-and-white negative photographic materials, comparison of temperature parameters of the gas-chromatographic separation of various organic compounds, toxicity characterization (LD 50) of homologues using C 3–C 12 1-alkanols as an example, and the possibility of predicting sample preparation operations in the determination of drugs in blood plasma based on their physicochemical characteristics. The main features of data interpretation characterized by a high degree of uncertainty are revealed. It is noted that important conclusions can be drawn based on the facts of low reproducibility (one-dimensional arrays) or poor correlation of variables (two-dimensional arrays).

Translated title of the contributionособенности обработки и интерпретации аналитических данных с высокой степенью неопределенности
Original languageEnglish
Pages (from-to)1399-1412
Number of pages14
JournalJournal of Analytical Chemistry
Volume77
Issue number11
DOIs
StatePublished - 1 Nov 2022

    Scopus subject areas

  • Chemistry(all)
  • Analytical Chemistry

    Research areas

  • blood plasma, data arrays, drug preparations, examples of various tasks, high uncertainty, hydrophobicity factors, interpretation, sample preparation

ID: 100121638