Scaffold-generating transformations of the Groebke-Blackburn-Bienaymé (GBB) reaction products are reviewed. The literature cases were grouped according to the reactions employed as the post-condensational event as follows: lactamization, intramolecular arylation, intramolecular Michael addition, cyclizations involving an alkyne moiety and miscellaneous. Although synthetic strategic based on the post-GBB modifications have been exploited to a lesser extent compared to post-Ugi modifications, the interest of researchers to the GBB reaction as the platform for designing new polycyclic scaffolds has been on the rise in the past decade.