Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
Neuropsychiatric side of the COVID-19. / Mayorova, Margarita A. ; Churilov, Leonid P. ; Petrova, Natalia N.; Shoenfeld, Yehuda .
Autoimmunity, COVID-19, Post-COVID-19 Syndrome and COVID-19 Vaccination. ed. / Yehuda shoenfeld. 2023. p. 405-426.Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
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TY - CHAP
T1 - Neuropsychiatric side of the COVID-19
AU - Mayorova, Margarita A.
AU - Churilov, Leonid P.
AU - Petrova, Natalia N.
AU - Shoenfeld, Yehuda
PY - 2023
Y1 - 2023
N2 - The latest data shows the wide spectrum of various neuropsychiatric manifestations of COVID-19 often persisting after its acute phase. Neuropsychiatric complications of COVID-19 include various neural impairments (fatigue, headache, dizziness, anxiety, cognitive dysfunction, sleep and mood disturbances, muscle soreness, stroke, seizures, encephalitis, ataxia, myelitis, anosmia, ageusia, Guillain-Barré syndrome, and Miller Fisher syndrome) as the development of a full clinical picture of psychiatric diseases (psychotic, anxiety, and affective spectrum). Symptoms of post-COVID syndrome may persist even a year after discharge and are associated with a high risk of suicidal behavior in virus survivors. Currently, possible mechanisms of COVID-19 effect on the central nervous system include indirect (cytokine storm, hypoxia, acute respiratory distress syndrome, neuroinflammation, postinfection autoimmunity) and possible direct COVID-19-induced neuronal/vascular damage (including direct PAMP-like effect of SARS-CoV-2 components on Toll-like receptors of glia). Autoimmune and immunopathological links of COVID-19 pathogenesis also may play a role in its neuropsychiatric complications. COVID-19 is known for high rates of morbidity and mortality. Early recognition of neuropsychiatric manifestations, adequate treatment, and long-term follow-up are needed to provide efficient patient care.
AB - The latest data shows the wide spectrum of various neuropsychiatric manifestations of COVID-19 often persisting after its acute phase. Neuropsychiatric complications of COVID-19 include various neural impairments (fatigue, headache, dizziness, anxiety, cognitive dysfunction, sleep and mood disturbances, muscle soreness, stroke, seizures, encephalitis, ataxia, myelitis, anosmia, ageusia, Guillain-Barré syndrome, and Miller Fisher syndrome) as the development of a full clinical picture of psychiatric diseases (psychotic, anxiety, and affective spectrum). Symptoms of post-COVID syndrome may persist even a year after discharge and are associated with a high risk of suicidal behavior in virus survivors. Currently, possible mechanisms of COVID-19 effect on the central nervous system include indirect (cytokine storm, hypoxia, acute respiratory distress syndrome, neuroinflammation, postinfection autoimmunity) and possible direct COVID-19-induced neuronal/vascular damage (including direct PAMP-like effect of SARS-CoV-2 components on Toll-like receptors of glia). Autoimmune and immunopathological links of COVID-19 pathogenesis also may play a role in its neuropsychiatric complications. COVID-19 is known for high rates of morbidity and mortality. Early recognition of neuropsychiatric manifestations, adequate treatment, and long-term follow-up are needed to provide efficient patient care.
KW - COVID-19
KW - neuroinflammation
KW - Neuropsychiatric complications
KW - Post-COVID syndrome
KW - Post-infection autoimmunity
KW - Psychiatric disorders
U2 - 10.1016/B978-0-443-18566-3.00007-4
DO - 10.1016/B978-0-443-18566-3.00007-4
M3 - Chapter
SN - 9780443185663
SP - 405
EP - 426
BT - Autoimmunity, COVID-19, Post-COVID-19 Syndrome and COVID-19 Vaccination
A2 - shoenfeld, Yehuda
ER -
ID: 106635474