Research output: Contribution to journal › Article › peer-review
Microextraction of sulfonamides from chicken meat samples in three-component deep eutectic solvent. / Shishov, Andrey; Gorbunov, Artem; Baranovskii, Egor; Bulatov, Andrey.
In: Microchemical Journal, Vol. 158, 105274, 11.2020.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Microextraction of sulfonamides from chicken meat samples in three-component deep eutectic solvent
AU - Shishov, Andrey
AU - Gorbunov, Artem
AU - Baranovskii, Egor
AU - Bulatov, Andrey
N1 - Funding Information: The study was supported by a grant from the President of the Russian Federation MK-1154.2020.3. Scientific research was partially performed at Chemical Analysis and Materials Research Centre of Saint Petersburg State University . Publisher Copyright: © 2020 Copyright: Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/11
Y1 - 2020/11
N2 - An effective approach for the sample pretreatment of solid food samples based on the use of three-component deep eutectic solvent (quaternary ammonium salt, carboxylic acid and medium chain fatty acid) was developed. Each component of deep eutectic solvent played a key role for separation of target analytes from solid-phase sample and their preconcentration based on dispersive liquid–liquid microextraction. The approach was applied for the HPLC-UV determination of sulfamethazine and sulfamethoxazole in chicken meat samples. The effect of deep eutectic solvents composition on the efficiency of both sample pretreatment steps was investigated. It was found that the solvent based on tetrabutylammonium bromide, malonic acid and hexanoic acid (1:1:1, mol/mol) provided the most effective separation and preconcentration of sulfanilamides. The procedure included mixing of solid food sample and deep eutectic solvent. By this sample pretreatment step, sulfanilamides were extracted into the solvent phase. For preconcentration of sulfanilamides, aqueous phase was injected into the deep eutectic solvent phase, resulting in its decomposition and the formation of hexanoic acid dispersed in aqueous phase. After phase separation, hexanoic acid phase containing sulfanilamides was withdrawn for HPLC-UV analysis. Under optimal conditions, the limits of detection calculated from a blank test based on 3σ were 3 µg kg−1 and 7 µg kg−1 for sulfamethoxazole and sulfamethazine, respectively.
AB - An effective approach for the sample pretreatment of solid food samples based on the use of three-component deep eutectic solvent (quaternary ammonium salt, carboxylic acid and medium chain fatty acid) was developed. Each component of deep eutectic solvent played a key role for separation of target analytes from solid-phase sample and their preconcentration based on dispersive liquid–liquid microextraction. The approach was applied for the HPLC-UV determination of sulfamethazine and sulfamethoxazole in chicken meat samples. The effect of deep eutectic solvents composition on the efficiency of both sample pretreatment steps was investigated. It was found that the solvent based on tetrabutylammonium bromide, malonic acid and hexanoic acid (1:1:1, mol/mol) provided the most effective separation and preconcentration of sulfanilamides. The procedure included mixing of solid food sample and deep eutectic solvent. By this sample pretreatment step, sulfanilamides were extracted into the solvent phase. For preconcentration of sulfanilamides, aqueous phase was injected into the deep eutectic solvent phase, resulting in its decomposition and the formation of hexanoic acid dispersed in aqueous phase. After phase separation, hexanoic acid phase containing sulfanilamides was withdrawn for HPLC-UV analysis. Under optimal conditions, the limits of detection calculated from a blank test based on 3σ were 3 µg kg−1 and 7 µg kg−1 for sulfamethoxazole and sulfamethazine, respectively.
KW - Deep eutectic solvent
KW - Dispersive liquid–liquid microextraction
KW - Food sample
KW - HPLC-UV
KW - Sample pretreatment
KW - Sulfonamides
KW - PRECONCENTRATION
KW - SOLIDIFICATION
KW - FRUIT JUICE
KW - CHROMATOGRAPHY
KW - EXTRACTION
KW - TRACE ANALYSIS
KW - LIQUID-LIQUID MICROEXTRACTION
KW - Dispersive liquid-liquid microextraction
KW - PESTICIDE-RESIDUES
KW - EFFICIENT
KW - SPECTROMETRY
UR - http://www.scopus.com/inward/record.url?scp=85088015006&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/8cde386e-b11b-3143-a688-50e363a65090/
U2 - 10.1016/j.microc.2020.105274
DO - 10.1016/j.microc.2020.105274
M3 - Article
AN - SCOPUS:85088015006
VL - 158
JO - Microchemical Journal
JF - Microchemical Journal
SN - 0026-265X
M1 - 105274
ER -
ID: 70790975