Objective: To compare diagnostic capability of mammography and mammoscintigraphy with Tc-methoxyisobutylisoni-trile (MIBI) in diagnostic of multicentric breast cancer. Material and Methods: We respectively analyzed 437 consecutive women with suspected breast cancer between 2014 to 2016. All of them underwent mammography and mammoscintigraphy. Craniocaudal and mediolateral oblique images were obtained. Mammoscintigraphy was performed 15-20 min. after intravenous injection 740 MBq of Tc-methoxyisobutylisoni-trile (MIBI). Final interpretation of the data was done according to histological examination. Results: Breast cancer was detect in 367(84%) of patients. Most of them 320(87%) had single node breast cancer and 47(13%) - multicentric breast cancer. Sensitivity, specificity and accuracy in diagnostic of multicentric breast cancer were 40,4%, 95,3%, 88% for mammography and 83%, 98%, 96% for mammoscintigraphy respectively. The combination of these methods allowed significantly increase sensitivity of breast cancer detection up to 93,6%. Specificity was 93,4%.