Lampbrush chromosome studies in the post-genomic era

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Lampbrush chromosome studies in the post-genomic era. / Krasikova, Alla; Fishman, Veniamin; Kulikova, Tatiana.

In: BioEssays, Vol. 45, No. 5, 05.2023, p. e2200250.

Research output: Contribution to journal › Article › peer-review

BibTeX

@article{3432332f56594cc6802b98f0adbec67a,

title = "Lampbrush chromosome studies in the post-genomic era",

abstract = "Extraordinary extended lampbrush chromosomes with thousands of transcription loops are favorable objects in chromosome biology. Chromosomes become lampbrushy due to unusually high rate of transcription during oogenesis. However, until recently, the information on the spectrum of transcribed sequences as well as genomic context of individual chromomeres was mainly limited to tandemly repetitive elements. Here we briefly outline novel findings and future directions in lampbrush chromosome studies in the post-genomic era. We emphasize the fruitfulness of combining genome-wide approaches with microscopy imaging techniques using lampbrush chromosomes as a remarkable model object. We believe that new data on the spectrum of sequences transcribed on the lateral loops of lampbrush chromosomes and their structural organization push the boundaries in the discussion of their biological role. Also see the video abstract here: https://youtu.be/zexoHfzX9rM.",

keywords = "chromatin domains, chromomere, hypertranscription, lampbrush chromosomes, nascent RNA, transcription loop, transcription unit",

author = "Alla Krasikova and Veniamin Fishman and Tatiana Kulikova",

note = "{\textcopyright} 2023 Wiley Periodicals LLC.",

year = "2023",

month = may,

doi = "10.1002/bies.202200250",

language = "English",

volume = "45",

pages = "e2200250",

journal = "BioEssays",

issn = "0265-9247",

publisher = "Wiley-Blackwell",

number = "5",

}

RIS

TY - JOUR

T1 - Lampbrush chromosome studies in the post-genomic era

AU - Krasikova, Alla

AU - Fishman, Veniamin

AU - Kulikova, Tatiana

PY - 2023/5

Y1 - 2023/5

N2 - Extraordinary extended lampbrush chromosomes with thousands of transcription loops are favorable objects in chromosome biology. Chromosomes become lampbrushy due to unusually high rate of transcription during oogenesis. However, until recently, the information on the spectrum of transcribed sequences as well as genomic context of individual chromomeres was mainly limited to tandemly repetitive elements. Here we briefly outline novel findings and future directions in lampbrush chromosome studies in the post-genomic era. We emphasize the fruitfulness of combining genome-wide approaches with microscopy imaging techniques using lampbrush chromosomes as a remarkable model object. We believe that new data on the spectrum of sequences transcribed on the lateral loops of lampbrush chromosomes and their structural organization push the boundaries in the discussion of their biological role. Also see the video abstract here: https://youtu.be/zexoHfzX9rM.

AB - Extraordinary extended lampbrush chromosomes with thousands of transcription loops are favorable objects in chromosome biology. Chromosomes become lampbrushy due to unusually high rate of transcription during oogenesis. However, until recently, the information on the spectrum of transcribed sequences as well as genomic context of individual chromomeres was mainly limited to tandemly repetitive elements. Here we briefly outline novel findings and future directions in lampbrush chromosome studies in the post-genomic era. We emphasize the fruitfulness of combining genome-wide approaches with microscopy imaging techniques using lampbrush chromosomes as a remarkable model object. We believe that new data on the spectrum of sequences transcribed on the lateral loops of lampbrush chromosomes and their structural organization push the boundaries in the discussion of their biological role. Also see the video abstract here: https://youtu.be/zexoHfzX9rM.

KW - chromatin domains

KW - chromomere

KW - hypertranscription

KW - lampbrush chromosomes

KW - nascent RNA

KW - transcription loop

KW - transcription unit

UR - https://www.mendeley.com/catalogue/d0c80b48-7b49-3743-aab7-a77ad40ea9ed/

U2 - 10.1002/bies.202200250

DO - 10.1002/bies.202200250

M3 - Article

C2 - 36855056

VL - 45

SP - e2200250

JO - BioEssays

JF - BioEssays

SN - 0265-9247

IS - 5

ER -

ID: 104348342