Research output: Contribution to journal › Review article › peer-review
Immunological Disorders: Gradations and the Current Approach in Laboratory Diagnostics. / Старшинова, Анна Андреевна; Савченко , А.А.; Борисов, А.Г.; Кудрявцев, Игорь Владимирович; Рубинштейн, Артем Аркадьевич; Довгалюк, Ирина; Кульпина, Анастасия Ярославовна; Чурилов, Леонид Павлович; Соболевская, Полина Анатольевна; Федоткина, Тамара Викторовна; Кудлай, Дмитрий Анатольевич; Шляхто, Евгений Владимирович.
In: Pathophysiology, Vol. 32, No. 2, 17, 18.04.2025.Research output: Contribution to journal › Review article › peer-review
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TY - JOUR
T1 - Immunological Disorders: Gradations and the Current Approach in Laboratory Diagnostics
AU - Старшинова, Анна Андреевна
AU - Савченко , А.А.
AU - Борисов, А.Г.
AU - Кудрявцев, Игорь Владимирович
AU - Рубинштейн, Артем Аркадьевич
AU - Довгалюк, Ирина
AU - Кульпина, Анастасия Ярославовна
AU - Чурилов, Леонид Павлович
AU - Соболевская, Полина Анатольевна
AU - Федоткина, Тамара Викторовна
AU - Кудлай, Дмитрий Анатольевич
AU - Шляхто, Евгений Владимирович
PY - 2025/4/18
Y1 - 2025/4/18
N2 - Currently, understanding the immune response, its abnormalities, and its diagnostic possibilities is a key point in the management of patients with various diseases, from infectious to oncological ones. The aim of this review was to analyze the data presented in the current literature on immune disorders and the possibility of their laboratory diagnostics in combination with clinical manifestations. We have performed a systematic analysis of the literature presented in international databases over the last ten years. We have presented data on the possibility of diagnosing immunopathological processes due to changes in immune cells and soluble molecules involved in the pathogenesis of a wide range of diseases, as well as the determination of antibodies to detect autoimmune processes. By applying laboratory techniques such as hematology, flow cytometry, ELISA, etc., available to most clinical laboratories worldwide, clinical data on immune system dysfunction in a wide range of diseases are being collected. This process is unfortunately still very far from being completed. However, with all the diversity of accumulated knowledge, we can currently state that the pathogenesis of the vast majority of immune-mediated diseases is not yet known. At the same time, the current success in dividing immune-mediated diseases into distinct clusters based on different types of inflammatory responses that are based on the involvement of different populations of T helper cells and cytokine molecules represents significant progress. Further research in this direction seems very promising, as it allows the identification of new target cells and target molecules for both improved diagnostics and targeted therapies.
AB - Currently, understanding the immune response, its abnormalities, and its diagnostic possibilities is a key point in the management of patients with various diseases, from infectious to oncological ones. The aim of this review was to analyze the data presented in the current literature on immune disorders and the possibility of their laboratory diagnostics in combination with clinical manifestations. We have performed a systematic analysis of the literature presented in international databases over the last ten years. We have presented data on the possibility of diagnosing immunopathological processes due to changes in immune cells and soluble molecules involved in the pathogenesis of a wide range of diseases, as well as the determination of antibodies to detect autoimmune processes. By applying laboratory techniques such as hematology, flow cytometry, ELISA, etc., available to most clinical laboratories worldwide, clinical data on immune system dysfunction in a wide range of diseases are being collected. This process is unfortunately still very far from being completed. However, with all the diversity of accumulated knowledge, we can currently state that the pathogenesis of the vast majority of immune-mediated diseases is not yet known. At the same time, the current success in dividing immune-mediated diseases into distinct clusters based on different types of inflammatory responses that are based on the involvement of different populations of T helper cells and cytokine molecules represents significant progress. Further research in this direction seems very promising, as it allows the identification of new target cells and target molecules for both improved diagnostics and targeted therapies.
KW - immune cells
KW - immunological disorders
KW - immunopathology
KW - laboratory diagnostics
KW - molecules
KW - systemic inflammatory response
UR - https://www.mdpi.com/1873-149X/32/2/17
UR - https://www.mendeley.com/catalogue/904481d5-b80a-37a0-b2cf-003082321866/
U2 - 10.3390/pathophysiology32020017
DO - 10.3390/pathophysiology32020017
M3 - Review article
C2 - 40265442
VL - 32
JO - Pathophysiology
JF - Pathophysiology
SN - 0928-4680
IS - 2
M1 - 17
ER -
ID: 136127767