Hybrid systems for oral delivery of a therapeutic neuropeptide

Research output: Contribution to journal › Article › peer-review

Department of Nuclear Physics Research Methods

DOI

https://doi.org/10.1016/j.mencom.2020.01.008
Final published version

Natalia N. Sudareva
Olga M. Suvorova
Irina I. Tarasenko
Natalia N. Saprykina
Natalia V. Smirnova
Sergey G. Petunov
Andrey S. Radilov
Alexander S. Timin
Evgenia G. Korzhikova-Vlakh
Alexander D. Vilesov

Several hybrid systems for oral delivery of a therapeutic peptide have been prepared and investigated. Poly(l-glutamic acidco-d-phenylalanine) and silica sub-microparticles, porous CaCO₃ microparticles and Lycopodium clavatum spore capsules were employed as the first level carriers included in sodium alginate granules as the second level carriers. Efficiency of the peptide encapsulation and release rate strongly depended on the nature and structure of the carriers.

Original language	English
Pages (from-to)	25-27
Number of pages	3
Journal	Mendeleev Communications
Volume	30
Issue number	1
DOIs	https://doi.org/10.1016/j.mencom.2020.01.008
State	Published - 1 Jan 2020

Research areas

alginate granules, encapsulation, peptide delivery systems, poly(amino acids), silica and CaCO sub-microparticles, sporopollenin exine capsules, PROTEIN, DRUG-DELIVERY, ENCAPSULATION, RELEASE, CALCIUM-CARBONATE, NANOPARTICLES, PEPTIDES, MICROCAPSULES, silica and CaCO3 sub-microparticles

Scopus subject areas

Chemistry(all)

ID: 70760469