Hemagglutinin codon optimization : a promising tool for enhancing the immunogenicity of influenza virus vaccines. / Fedorova, E. A.; Kiseleva, I. V.; Auewarakul, P.; Suptawiwat, O.; Rudenko, L. G.
In: Molecular Genetics, Microbiology and Virology, Vol. 29, No. 4, 2014, p. 159-166.Research output: Contribution to journal › Review article › peer-review
}
TY - JOUR
T1 - Hemagglutinin codon optimization
T2 - a promising tool for enhancing the immunogenicity of influenza virus vaccines
AU - Fedorova, E. A.
AU - Kiseleva, I. V.
AU - Auewarakul, P.
AU - Suptawiwat, O.
AU - Rudenko, L. G.
N1 - Publisher Copyright: © 2014, Allerton Press, Inc. Copyright: Copyright 2016 Elsevier B.V., All rights reserved.
PY - 2014
Y1 - 2014
N2 - Modification of the codon bias of gene sequences is a promising tool of gene expression control. This review presents the theoretical basis of the codon optimization and summarizes the published data on experimental modification of the codon bias of viral genes for the purposes of vaccine development. Studies aimed at enhancing the immunogenicity of influenza vaccines by means of codon optimization are discussed in detail. The prospects of applying the codon optimization technique for the development of influenza vaccines are analyzed.
AB - Modification of the codon bias of gene sequences is a promising tool of gene expression control. This review presents the theoretical basis of the codon optimization and summarizes the published data on experimental modification of the codon bias of viral genes for the purposes of vaccine development. Studies aimed at enhancing the immunogenicity of influenza vaccines by means of codon optimization are discussed in detail. The prospects of applying the codon optimization technique for the development of influenza vaccines are analyzed.
KW - codon optimization
KW - immunogenicity
KW - influenza vaccine
KW - influenza virus
UR - http://www.scopus.com/inward/record.url?scp=84961358603&partnerID=8YFLogxK
U2 - 10.3103/S089141681404003X
DO - 10.3103/S089141681404003X
M3 - Review article
AN - SCOPUS:84961358603
VL - 29
SP - 159
EP - 166
JO - Molecular Genetics, Microbiology and Virology
JF - Molecular Genetics, Microbiology and Virology
SN - 0891-4168
IS - 4
ER -
ID: 75087861