A series of N-aryl α-fluoro-γ-lactams were successfully prepared by hydrofluorination of diazo counterparts with the Olah reagent in moderate yields. This approach was also applied to bromofluorination with N-bromosuccinimide as electrophilic bromine source.

Original languageEnglish
Article number152969
Number of pages4
JournalTetrahedron Letters
Volume69
Early online date2 Mar 2021
DOIs
StatePublished - 13 Apr 2021

    Research areas

  • Diazo compounds, N-aryl 2-pyrrolidones, The Olah reagent, α-Fluorination of carbonyl compounds, alpha-Fluorination of carbonyl compounds

    Scopus subject areas

  • Drug Discovery
  • Biochemistry
  • Organic Chemistry

ID: 75206821