Research output: Contribution to journal › Article › peer-review
Evolution of P-wave indices during long-Term follow-up as markers of atrial substrate progression in arrhythmogenic right ventricular cardiomyopathy. / Baturova, Maria A.; Svensson, Anneli; Aneq, Meriam Åström; Svendsen, Jesper H.; Risum, Niels; Sherina, Valeriia; Bundgaard, Henning; Meurling, Carl; Lundin, Catarina; Carlson, Jonas; Platonov, Pyotr G.
In: Europace, Vol. 23, No. 23 Suppl 1, 01.03.2021, p. I29-I37.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Evolution of P-wave indices during long-Term follow-up as markers of atrial substrate progression in arrhythmogenic right ventricular cardiomyopathy
AU - Baturova, Maria A.
AU - Svensson, Anneli
AU - Aneq, Meriam Åström
AU - Svendsen, Jesper H.
AU - Risum, Niels
AU - Sherina, Valeriia
AU - Bundgaard, Henning
AU - Meurling, Carl
AU - Lundin, Catarina
AU - Carlson, Jonas
AU - Platonov, Pyotr G.
N1 - Publisher Copyright: © 2021 Published on behalf of the European Society of Cardiology. All rights reserved.
PY - 2021/3/1
Y1 - 2021/3/1
N2 - Aims: Patients with arrhythmogenic right ventricular cardiomyopathy (ARVC) have increased prevalence of atrial arrhythmias indicating atrial involvement in the disease. We aimed to assess the long-Term evolution of P-wave indices as electrocardiographic (ECG) markers of atrial substrate during ARVC progression. Methods and results: We included 100 patients with a definite ARVC diagnosis according to 2010 Task Force criteria [34% females, median age 41 (inter-quartile range 30-55) years]. All available sinus rhythm ECGs (n = 1504) were extracted from the regional electronic ECG databases and automatically processed using Glasgow algorithm. P-wave duration, P-wave area, P-wave frontal axis, and prevalence of abnormal P terminal force in lead V1 (aPTF-V1) were assessed and compared at ARVC diagnosis, 10 years before and up to 15 years after diagnosis. Prior to ARVC diagnosis, none of the P-wave indices differed significantly from the data at ARVC diagnosis. After ascertainment of ARVC diagnosis, P-wave area in lead V1 decreased from-1 to-30 μV ms at 5 years (P = 0.002). P-wave area in lead V2 decreased from 82 μV ms at ARVC diagnosis to 42 μV ms 10 years after ARVC diagnosis (P = 0.006). The prevalence of aPTF-V1 increased from 5% at ARVC diagnosis to 18% by the 15th year of follow-up (P = 0.004). P-wave duration and frontal axis did not change during disease progression. Conclusion: Initial ARVC progression was associated with P-wave flattening in right precordial leads and in later disease stages an increased prevalence of aPTF-V1 was seen.
AB - Aims: Patients with arrhythmogenic right ventricular cardiomyopathy (ARVC) have increased prevalence of atrial arrhythmias indicating atrial involvement in the disease. We aimed to assess the long-Term evolution of P-wave indices as electrocardiographic (ECG) markers of atrial substrate during ARVC progression. Methods and results: We included 100 patients with a definite ARVC diagnosis according to 2010 Task Force criteria [34% females, median age 41 (inter-quartile range 30-55) years]. All available sinus rhythm ECGs (n = 1504) were extracted from the regional electronic ECG databases and automatically processed using Glasgow algorithm. P-wave duration, P-wave area, P-wave frontal axis, and prevalence of abnormal P terminal force in lead V1 (aPTF-V1) were assessed and compared at ARVC diagnosis, 10 years before and up to 15 years after diagnosis. Prior to ARVC diagnosis, none of the P-wave indices differed significantly from the data at ARVC diagnosis. After ascertainment of ARVC diagnosis, P-wave area in lead V1 decreased from-1 to-30 μV ms at 5 years (P = 0.002). P-wave area in lead V2 decreased from 82 μV ms at ARVC diagnosis to 42 μV ms 10 years after ARVC diagnosis (P = 0.006). The prevalence of aPTF-V1 increased from 5% at ARVC diagnosis to 18% by the 15th year of follow-up (P = 0.004). P-wave duration and frontal axis did not change during disease progression. Conclusion: Initial ARVC progression was associated with P-wave flattening in right precordial leads and in later disease stages an increased prevalence of aPTF-V1 was seen.
KW - Arrhythmogenic cardiomyopathy
KW - Atrial fibrillation
KW - P-Terminal force in lead V1
KW - P-wave area in lead V1
KW - P-wave area in lead V2
KW - Follow-Up Studies
KW - Humans
KW - Middle Aged
KW - Arrhythmogenic Right Ventricular Dysplasia/diagnosis
KW - Male
KW - Arrhythmias, Cardiac
KW - Biomarkers
KW - Electrocardiography
KW - Adult
KW - Female
KW - P-terminal force in lead V1
UR - http://www.scopus.com/inward/record.url?scp=85103433165&partnerID=8YFLogxK
U2 - 10.1093/europace/euaa388
DO - 10.1093/europace/euaa388
M3 - Article
C2 - 33751075
AN - SCOPUS:85103433165
VL - 23
SP - I29-I37
JO - Europace
JF - Europace
SN - 1099-5129
IS - 23 Suppl 1
ER -
ID: 84461646