DOI

  • Maria A. Baturova
  • Anneli Svensson
  • Meriam Åström Aneq
  • Jesper H. Svendsen
  • Niels Risum
  • Valeriia Sherina
  • Henning Bundgaard
  • Carl Meurling
  • Catarina Lundin
  • Jonas Carlson
  • Pyotr G. Platonov

Aims: Patients with arrhythmogenic right ventricular cardiomyopathy (ARVC) have increased prevalence of atrial arrhythmias indicating atrial involvement in the disease. We aimed to assess the long-Term evolution of P-wave indices as electrocardiographic (ECG) markers of atrial substrate during ARVC progression. Methods and results: We included 100 patients with a definite ARVC diagnosis according to 2010 Task Force criteria [34% females, median age 41 (inter-quartile range 30-55) years]. All available sinus rhythm ECGs (n = 1504) were extracted from the regional electronic ECG databases and automatically processed using Glasgow algorithm. P-wave duration, P-wave area, P-wave frontal axis, and prevalence of abnormal P terminal force in lead V1 (aPTF-V1) were assessed and compared at ARVC diagnosis, 10 years before and up to 15 years after diagnosis. Prior to ARVC diagnosis, none of the P-wave indices differed significantly from the data at ARVC diagnosis. After ascertainment of ARVC diagnosis, P-wave area in lead V1 decreased from-1 to-30 μV ms at 5 years (P = 0.002). P-wave area in lead V2 decreased from 82 μV ms at ARVC diagnosis to 42 μV ms 10 years after ARVC diagnosis (P = 0.006). The prevalence of aPTF-V1 increased from 5% at ARVC diagnosis to 18% by the 15th year of follow-up (P = 0.004). P-wave duration and frontal axis did not change during disease progression. Conclusion: Initial ARVC progression was associated with P-wave flattening in right precordial leads and in later disease stages an increased prevalence of aPTF-V1 was seen.

Original languageEnglish
Pages (from-to)I29-I37
Number of pages9
JournalEuropace
Volume23
Issue number23 Suppl 1
DOIs
StatePublished - 1 Mar 2021

    Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

    Research areas

  • Arrhythmogenic cardiomyopathy, Atrial fibrillation, P-Terminal force in lead V1, P-wave area in lead V1, P-wave area in lead V2, Follow-Up Studies, Humans, Middle Aged, Arrhythmogenic Right Ventricular Dysplasia/diagnosis, Male, Arrhythmias, Cardiac, Biomarkers, Electrocardiography, Adult, Female, P-terminal force in lead V1

ID: 84461646