Using voltage-clamp technique, the involvement of epoxygenases in immunomodulatory drug glutoxim
regulation of Na+ transport in frog skin was investigated. We have shown for the first time that preincubation
of the frog skin with epoxygenase inhibitors econazole or proadifen almost completely inhibits the
stimulatory effect of glutoxim on Na+ transport. The data suggest the involvement of the enzymes and/or
products of epoxygenase oxidation pathway of arachidonic acid metabolism in glutoxim effect on Na+ transport
in frog skin epithelium.