Research output: Contribution to journal › Article › peer-review
A facile approach to novel medicinally relevant spiro heterocyclic scaffolds (namely furan-2(5 H)-ones, tetrahydrofurans and pyrans spiro-conjugated with the succinimide ring) has been developed. The protocol consists of Rh(II)-catalyzed insertion of heterocyclic carbenes derived from diazoarylidene succinimides (DAS) into the O-H bond of propiolic/allenic acids or brominated alcohols, followed by base-promoted cyclization to afford the target spirocyclic compounds in good to high yields.
Original language | English |
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Pages (from-to) | 561–569 |
Number of pages | 9 |
Journal | Beilstein Journal of Organic Chemistry |
Volume | 20 |
DOIs | |
State | Published - 11 Mar 2024 |
ID: 117623629