Research output: Contribution to journal › Article › peer-review
Effective delivery of porphyrazine photosensitizers to cancer cells by polymer brush nanocontainers. / Shilyagina, Natalia Y.; Peskova, Nina N.; Lermontova, Svetlana A.; Brilkina, Anna A.; Vodeneev, Vladimir A.; Yakimansky, Alexander V.; Klapshina, Larisa G.; Balalaeva, Irina V.
In: Journal of Biophotonics, Vol. 10, No. 9, 01.09.2017, p. 1189-1197.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Effective delivery of porphyrazine photosensitizers to cancer cells by polymer brush nanocontainers
AU - Shilyagina, Natalia Y.
AU - Peskova, Nina N.
AU - Lermontova, Svetlana A.
AU - Brilkina, Anna A.
AU - Vodeneev, Vladimir A.
AU - Yakimansky, Alexander V.
AU - Klapshina, Larisa G.
AU - Balalaeva, Irina V.
PY - 2017/9/1
Y1 - 2017/9/1
N2 - Efficient drug delivery can be assigned to tasks that attract the most acute attention of researchers in the field of anticancer drug design. We have reported the first case of using amphiphilic polymer brushes as nanocontainers for photosensitizer delivery to cancer cells. Regular graft-copolymers of hydrophobic polyimides with hydrophilic polymethacrylic acid side chains were loaded with photosensitive dye tetra(4-fluorophenyl)tetracyanoporphyrazine (Pz) providing a sufficiently stable homogeneous fraction of fluorescent Pz-loaded nanoparticles with a size of 100–150 nm. Pz-loaded polymer brushes were substantially more efficient for Pz delivery into cells compared with other types of particles examined, Pz-polyethyleneglycol and Pz-methylcellulose. In vivo, an efficient Pz delivery to tumor can also be expected since the Pz-PB particle size is in the optimal range for passive targeting. Pz-PB showed pronounced photodynamic activity, while, that is important, in the absence of irradiation the PB carrier itself was significantly less toxic than the dye itself. (Figure presented.) Summing up, water-soluble polymer brushes with polyimide backbones and polymethacrylic acid side chains can be regarded as a novel type of nanocontainers providing efficient intracellular drug delivery for photodynamic therapy of cancers.
AB - Efficient drug delivery can be assigned to tasks that attract the most acute attention of researchers in the field of anticancer drug design. We have reported the first case of using amphiphilic polymer brushes as nanocontainers for photosensitizer delivery to cancer cells. Regular graft-copolymers of hydrophobic polyimides with hydrophilic polymethacrylic acid side chains were loaded with photosensitive dye tetra(4-fluorophenyl)tetracyanoporphyrazine (Pz) providing a sufficiently stable homogeneous fraction of fluorescent Pz-loaded nanoparticles with a size of 100–150 nm. Pz-loaded polymer brushes were substantially more efficient for Pz delivery into cells compared with other types of particles examined, Pz-polyethyleneglycol and Pz-methylcellulose. In vivo, an efficient Pz delivery to tumor can also be expected since the Pz-PB particle size is in the optimal range for passive targeting. Pz-PB showed pronounced photodynamic activity, while, that is important, in the absence of irradiation the PB carrier itself was significantly less toxic than the dye itself. (Figure presented.) Summing up, water-soluble polymer brushes with polyimide backbones and polymethacrylic acid side chains can be regarded as a novel type of nanocontainers providing efficient intracellular drug delivery for photodynamic therapy of cancers.
KW - drug delivery
KW - fluorescent molecular rotors
KW - photosensitizers
KW - polymer brushes
KW - porphyrazines
UR - http://www.scopus.com/inward/record.url?scp=85006086315&partnerID=8YFLogxK
U2 - 10.1002/jbio.201600212
DO - 10.1002/jbio.201600212
M3 - Article
AN - SCOPUS:85006086315
VL - 10
SP - 1189
EP - 1197
JO - Journal of Biophotonics
JF - Journal of Biophotonics
SN - 1864-063X
IS - 9
ER -
ID: 9320184