Research output: Contribution to journal › Article
Effect of two pyrazine-containing chemosignals on cells of bone marrow and testes in male house mice (Mus musculus L.). / Daev, E. V.; Vyborova, A. M.; Kazarova, V. E.; Dukel’skaya, A. V.
In: Journal of Evolutionary Biochemistry and Physiology, Vol. 48, No. 1, 2012, p. 18-23.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of two pyrazine-containing chemosignals on cells of bone marrow and testes in male house mice (Mus musculus L.)
AU - Daev, E. V.
AU - Vyborova, A. M.
AU - Kazarova, V. E.
AU - Dukel’skaya, A. V.
PY - 2012
Y1 - 2012
N2 - The evolutionarily conservative 2,5-dimethylpyrazine chemosignal, a pheromone released by female mice, has been shown to increase frequency of mitotic disturbances in bone marrow cells assessed by using metaphase and ana-telophase analyses. The substitution of methyl radical in the molecule of pheromone by carboxyl reveals specificity of the effect of the latter derivative: the frequency of disturbances revealed by the ana-telophase analysis alone increases, whereas no induction of disturbance is detected by the metaphase analysis. An increase of the anomalies induced by both compounds has been shown in a sperm head test. Possible mechanisms underlying specific action of the tested substances on stability of the genetic apparatus of bone marrow dividing cells in the house mouse are discussed.
AB - The evolutionarily conservative 2,5-dimethylpyrazine chemosignal, a pheromone released by female mice, has been shown to increase frequency of mitotic disturbances in bone marrow cells assessed by using metaphase and ana-telophase analyses. The substitution of methyl radical in the molecule of pheromone by carboxyl reveals specificity of the effect of the latter derivative: the frequency of disturbances revealed by the ana-telophase analysis alone increases, whereas no induction of disturbance is detected by the metaphase analysis. An increase of the anomalies induced by both compounds has been shown in a sperm head test. Possible mechanisms underlying specific action of the tested substances on stability of the genetic apparatus of bone marrow dividing cells in the house mouse are discussed.
KW - mouse – chemosignals – bone marrow – chromosomal aberrations – mitotic disturbances
U2 - 10.1134/S0022093012010033
DO - 10.1134/S0022093012010033
M3 - Article
VL - 48
SP - 18
EP - 23
JO - Journal of Evolutionary Biochemistry and Physiology
JF - Journal of Evolutionary Biochemistry and Physiology
SN - 0022-0930
IS - 1
ER -
ID: 5322403