• E. V. Daev
  • A. M. Vyborova
  • V. E. Kazarova
  • A. V. Dukel’skaya
The evolutionarily conservative 2,5-dimethylpyrazine chemosignal, a pheromone released by female mice, has been shown to increase frequency of mitotic disturbances in bone marrow cells assessed by using metaphase and ana-telophase analyses. The substitution of methyl radical in the molecule of pheromone by carboxyl reveals specificity of the effect of the latter derivative: the frequency of disturbances revealed by the ana-telophase analysis alone increases, whereas no induction of disturbance is detected by the metaphase analysis. An increase of the anomalies induced by both compounds has been shown in a sperm head test. Possible mechanisms underlying specific action of the tested substances on stability of the genetic apparatus of bone marrow dividing cells in the house mouse are discussed.
Original languageEnglish
Pages (from-to)18-23
JournalJournal of Evolutionary Biochemistry and Physiology
Volume48
Issue number1
DOIs
StatePublished - 2012

    Research areas

  • mouse – chemosignals – bone marrow – chromosomal aberrations – mitotic disturbances

ID: 5322403