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DNA polymerases at the eukaryotic replication fork thirty years after : Connection to cancer. / Pavlov, Youri I.; Zhuk, Anna S.; Stepchenkova, Elena I.

In: Cancers, Vol. 12, No. 12, 3489, 12.2020.

Research output: Contribution to journal › Review article › peer-review

Harvard

Pavlov, YI, Zhuk, AS & Stepchenkova, EI 2020, 'DNA polymerases at the eukaryotic replication fork thirty years after: Connection to cancer', Cancers, vol. 12, no. 12, 3489. https://doi.org/10.3390/cancers12123489, https://doi.org/10.3390/cancers12123489

APA

Pavlov, Y. I., Zhuk, A. S., & Stepchenkova, E. I. (2020). DNA polymerases at the eukaryotic replication fork thirty years after: Connection to cancer. Cancers, 12(12), [3489]. https://doi.org/10.3390/cancers12123489, https://doi.org/10.3390/cancers12123489

Vancouver

Pavlov YI, Zhuk AS, Stepchenkova EI. DNA polymerases at the eukaryotic replication fork thirty years after: Connection to cancer. Cancers. 2020 Dec;12(12). 3489. https://doi.org/10.3390/cancers12123489, https://doi.org/10.3390/cancers12123489

Author

Pavlov, Youri I. ; Zhuk, Anna S. ; Stepchenkova, Elena I. / DNA polymerases at the eukaryotic replication fork thirty years after : Connection to cancer. In: Cancers. 2020 ; Vol. 12, No. 12.

BibTeX

@article{c94b31de63e047eb837e77e947169e62,
title = "DNA polymerases at the eukaryotic replication fork thirty years after: Connection to cancer",
abstract = "Recent studies on tumor genomes revealed that mutations in genes of replicative DNA polymerases cause a predisposition for cancer by increasing genome instability. The past 10 years have uncovered exciting details about the structure and function of replicative DNA polymerases and the replication fork organization. The principal idea of participation of different polymerases in specific transactions at the fork proposed by Morrison and coauthors 30 years ago and later named “division of labor,” remains standing, with an amendment of the broader role of polymerase δ in the replication of both the lagging and leading DNA strands. However, cancer-associated mutations predominantly affect the catalytic subunit of polymerase ε that participates in leading strand DNA synthesis. We analyze how new findings in the DNA replication field help elucidate the polymerase variants{\textquoteright} effects on cancer.",
keywords = "Cancer predisposition, DNA polymerases, Mutation rates, Proofreading exonucleases, Replication fidelity",
author = "Pavlov, {Youri I.} and Zhuk, {Anna S.} and Stepchenkova, {Elena I.}",
note = "Publisher Copyright: {\textcopyright} 2020 by the authors. Licensee MDPI, Basel, Switzerland.",
year = "2020",
month = dec,
doi = "10.3390/cancers12123489",
language = "English",
volume = "12",
journal = "Cancers",
issn = "2072-6694",
publisher = "MDPI AG",
number = "12",

}

RIS

TY - JOUR

T1 - DNA polymerases at the eukaryotic replication fork thirty years after

T2 - Connection to cancer

AU - Pavlov, Youri I.

AU - Zhuk, Anna S.

AU - Stepchenkova, Elena I.

N1 - Publisher Copyright: © 2020 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2020/12

Y1 - 2020/12

N2 - Recent studies on tumor genomes revealed that mutations in genes of replicative DNA polymerases cause a predisposition for cancer by increasing genome instability. The past 10 years have uncovered exciting details about the structure and function of replicative DNA polymerases and the replication fork organization. The principal idea of participation of different polymerases in specific transactions at the fork proposed by Morrison and coauthors 30 years ago and later named “division of labor,” remains standing, with an amendment of the broader role of polymerase δ in the replication of both the lagging and leading DNA strands. However, cancer-associated mutations predominantly affect the catalytic subunit of polymerase ε that participates in leading strand DNA synthesis. We analyze how new findings in the DNA replication field help elucidate the polymerase variants’ effects on cancer.

AB - Recent studies on tumor genomes revealed that mutations in genes of replicative DNA polymerases cause a predisposition for cancer by increasing genome instability. The past 10 years have uncovered exciting details about the structure and function of replicative DNA polymerases and the replication fork organization. The principal idea of participation of different polymerases in specific transactions at the fork proposed by Morrison and coauthors 30 years ago and later named “division of labor,” remains standing, with an amendment of the broader role of polymerase δ in the replication of both the lagging and leading DNA strands. However, cancer-associated mutations predominantly affect the catalytic subunit of polymerase ε that participates in leading strand DNA synthesis. We analyze how new findings in the DNA replication field help elucidate the polymerase variants’ effects on cancer.

KW - Cancer predisposition

KW - DNA polymerases

KW - Mutation rates

KW - Proofreading exonucleases

KW - Replication fidelity

UR - http://www.scopus.com/inward/record.url?scp=85096654665&partnerID=8YFLogxK

U2 - 10.3390/cancers12123489

DO - 10.3390/cancers12123489

M3 - Review article

AN - SCOPUS:85096654665

VL - 12

JO - Cancers

JF - Cancers

SN - 2072-6694

IS - 12

M1 - 3489

ER -

ID: 88539461