Diazo-Based Construction of Heterocyclic Systems via a X–H Insertion/Cyclization Cascade

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Diazo-Based Construction of Heterocyclic Systems via a X–H Insertion/Cyclization Cascade. / Малкова, Ксения Павловна ; Дарьин, Дмитрий Викторович.

In: European Journal of Organic Chemistry, 30.10.2024.

Research output: Contribution to journal › Article › peer-review

BibTeX

@article{4933e3b1fbce41128f88e87c77e1e37e,

title = "Diazo-Based Construction of Heterocyclic Systems via a X–H Insertion/Cyclization Cascade",

abstract = "The X−H insertion reaction (X=heteroatom) of diazo compounds has emerged as an eminent and reliant approach for the construction of C−X bonds. By merging X−H insertion with the sequential ring-closing transformations, diverse heterocyclic systems can be obtained in a step-economical manner. In recent years, the X−H insertion/cyclization cascades and one-pot transformations attract more research attention, especially in the area of asymmetric synthesis. Concentrating on the assembly of N,O,S-heterocycles, this Concept elucidates the various combinations of X−H insertion reactions with cyclization via an addition to multiple bonds. The ring-forming strategies reviewed comprise of Michael-type and Conia-ene reactions, aldol condensation, and Mannich reaction.",

keywords = "Cascade transformations, Cyclization, Diazo compounds, Heterocycles, X−H insertion",

author = "Малкова, {Ксения Павловна} and Дарьин, {Дмитрий Викторович}",

year = "2024",

month = oct,

day = "30",

doi = "10.1002/ejoc.202400909",

language = "English",

journal = "European Journal of Organic Chemistry",

issn = "1434-193X",

publisher = "Wiley-Blackwell",

}

RIS

TY - JOUR

T1 - Diazo-Based Construction of Heterocyclic Systems via a X–H Insertion/Cyclization Cascade

AU - Малкова, Ксения Павловна

AU - Дарьин, Дмитрий Викторович

PY - 2024/10/30

Y1 - 2024/10/30

N2 - The X−H insertion reaction (X=heteroatom) of diazo compounds has emerged as an eminent and reliant approach for the construction of C−X bonds. By merging X−H insertion with the sequential ring-closing transformations, diverse heterocyclic systems can be obtained in a step-economical manner. In recent years, the X−H insertion/cyclization cascades and one-pot transformations attract more research attention, especially in the area of asymmetric synthesis. Concentrating on the assembly of N,O,S-heterocycles, this Concept elucidates the various combinations of X−H insertion reactions with cyclization via an addition to multiple bonds. The ring-forming strategies reviewed comprise of Michael-type and Conia-ene reactions, aldol condensation, and Mannich reaction.

AB - The X−H insertion reaction (X=heteroatom) of diazo compounds has emerged as an eminent and reliant approach for the construction of C−X bonds. By merging X−H insertion with the sequential ring-closing transformations, diverse heterocyclic systems can be obtained in a step-economical manner. In recent years, the X−H insertion/cyclization cascades and one-pot transformations attract more research attention, especially in the area of asymmetric synthesis. Concentrating on the assembly of N,O,S-heterocycles, this Concept elucidates the various combinations of X−H insertion reactions with cyclization via an addition to multiple bonds. The ring-forming strategies reviewed comprise of Michael-type and Conia-ene reactions, aldol condensation, and Mannich reaction.

KW - Cascade transformations

KW - Cyclization

KW - Diazo compounds

KW - Heterocycles

KW - X−H insertion

UR - https://www.mendeley.com/catalogue/727f50e0-03a2-3b49-a8db-fe35a8ef2609/

U2 - 10.1002/ejoc.202400909

DO - 10.1002/ejoc.202400909

M3 - Article

JO - European Journal of Organic Chemistry

JF - European Journal of Organic Chemistry

SN - 1434-193X

ER -

ID: 126591001