Dialkyl diazomalonates in transition-metal-free, thermally promoted, diastereoselective wolff β-lactam synthesis

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Institute of Chemistry

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DOI

https://doi.org/10.1055/s-0040-1707811
Final published version

Judith Synofzik
Olga Bakulina
Dmitry Dar'in
Grigory Kantin
Mikhail Krasavin

Metal-free, thermally promoted synthesis of 3-alkoxy-3-alkoxycarbonyl-2-azetidinones via the Wolff-Staudinger β-lactam synthesis using dialkyl diazomalonates is described. The reaction appears fairly general and delivers only one diastereomer.

Original language	English
Pages (from-to)	1273-1276
Number of pages	4
Journal	Synlett
Volume	31
Issue number	13
DOIs	https://doi.org/10.1055/s-0040-1707811
State	Published - 12 Aug 2020

Scopus subject areas

Organic Chemistry

Research areas

diazomalonates, metal-free, thermal, Wolff rearrangement, β-lactam, REARRANGEMENT, CYCLOADDITION, PYROLYSIS, beta-lactam

ID: 61589552