Destabilization and stabilization of poly(A) • poly(U) structure by platinum(II) compounds

Standard

Destabilization and stabilization of poly(A) • poly(U) structure by platinum(II) compounds. / Bogdanov, A. A.; Ivanov, Yu V.; Kasyanenko, N. A.; Potekhin, S. A.; Surzhik, M. A.; Timkovskii, A. L.; Feofanov, S. A.; Khusainova, R. S.; Yakoblev, K. I.

In: Biophysics, Vol. 53, No. 5, 10.2008, p. 341-343.

Research output: Contribution to journal › Article › peer-review

Harvard

Bogdanov, AA, Ivanov, YV, Kasyanenko, NA, Potekhin, SA, Surzhik, MA, Timkovskii, AL, Feofanov, SA, Khusainova, RS & Yakoblev, KI 2008, 'Destabilization and stabilization of poly(A) • poly(U) structure by platinum(II) compounds', Biophysics, vol. 53, no. 5, pp. 341-343. https://doi.org/10.1134/S0006350908050035

APA

Bogdanov, A. A., Ivanov, Y. V., Kasyanenko, N. A., Potekhin, S. A., Surzhik, M. A., Timkovskii, A. L., Feofanov, S. A., Khusainova, R. S., & Yakoblev, K. I. (2008). Destabilization and stabilization of poly(A) • poly(U) structure by platinum(II) compounds. Biophysics, 53(5), 341-343. https://doi.org/10.1134/S0006350908050035

Vancouver

Bogdanov AA, Ivanov YV, Kasyanenko NA, Potekhin SA, Surzhik MA, Timkovskii AL et al. Destabilization and stabilization of poly(A) • poly(U) structure by platinum(II) compounds. Biophysics. 2008 Oct;53(5):341-343. https://doi.org/10.1134/S0006350908050035

Author

Bogdanov, A. A. ; Ivanov, Yu V. ; Kasyanenko, N. A. ; Potekhin, S. A. ; Surzhik, M. A. ; Timkovskii, A. L. ; Feofanov, S. A. ; Khusainova, R. S. ; Yakoblev, K. I. / Destabilization and stabilization of poly(A) • poly(U) structure by platinum(II) compounds. In: Biophysics. 2008 ; Vol. 53, No. 5. pp. 341-343.

BibTeX

@article{a6160b3199b446f7b61c792424813d04,

title = "Destabilization and stabilization of poly(A) • poly(U) structure by platinum(II) compounds",

abstract = "A methodology for analyzing the intramolecular structural order of the polynucleotide duplex poly(A) • poly(U) has been developed on the basis of molecular biophysics. The combination of circular dichroism spectroscopy and differential scanning calorimetry was shown to be an optimal approach. It ensures the screening of a wide set of substances and interaction conditions and the choice of compound(s) capable of stabilizing the structure and increasing the biological activity of this duplex. The study is aimed at obtaining a new and highly active antiviral drug.",

keywords = "Polynucleotide interferon inducers, Structure-activity relationships",

author = "Bogdanov, {A. A.} and Ivanov, {Yu V.} and Kasyanenko, {N. A.} and Potekhin, {S. A.} and Surzhik, {M. A.} and Timkovskii, {A. L.} and Feofanov, {S. A.} and Khusainova, {R. S.} and Yakoblev, {K. I.}",

year = "2008",

month = oct,

doi = "10.1134/S0006350908050035",

language = "English",

volume = "53",

pages = "341--343",

journal = "Biophysics (Russian Federation)",

issn = "0006-3509",

publisher = "Springer Nature",

number = "5",

}

RIS

TY - JOUR

T1 - Destabilization and stabilization of poly(A) • poly(U) structure by platinum(II) compounds

AU - Bogdanov, A. A.

AU - Ivanov, Yu V.

AU - Kasyanenko, N. A.

AU - Potekhin, S. A.

AU - Surzhik, M. A.

AU - Timkovskii, A. L.

AU - Feofanov, S. A.

AU - Khusainova, R. S.

AU - Yakoblev, K. I.

PY - 2008/10

Y1 - 2008/10

N2 - A methodology for analyzing the intramolecular structural order of the polynucleotide duplex poly(A) • poly(U) has been developed on the basis of molecular biophysics. The combination of circular dichroism spectroscopy and differential scanning calorimetry was shown to be an optimal approach. It ensures the screening of a wide set of substances and interaction conditions and the choice of compound(s) capable of stabilizing the structure and increasing the biological activity of this duplex. The study is aimed at obtaining a new and highly active antiviral drug.

AB - A methodology for analyzing the intramolecular structural order of the polynucleotide duplex poly(A) • poly(U) has been developed on the basis of molecular biophysics. The combination of circular dichroism spectroscopy and differential scanning calorimetry was shown to be an optimal approach. It ensures the screening of a wide set of substances and interaction conditions and the choice of compound(s) capable of stabilizing the structure and increasing the biological activity of this duplex. The study is aimed at obtaining a new and highly active antiviral drug.

KW - Polynucleotide interferon inducers

KW - Structure-activity relationships

UR - http://www.scopus.com/inward/record.url?scp=59849113492&partnerID=8YFLogxK

U2 - 10.1134/S0006350908050035

DO - 10.1134/S0006350908050035

M3 - Article

VL - 53

SP - 341

EP - 343

JO - Biophysics (Russian Federation)

JF - Biophysics (Russian Federation)

SN - 0006-3509

IS - 5

ER -

ID: 5025247