Abstract: Since its inception, the method of capillary electrophoresis has developed into a powerful analytical tool for the analysis of food and environmental samples, forensic and bioanalytical analysis. The review considers the main trends in the development of the electrophoretic method: the use of nanomaterials as a fundamentally new approach to the electrophoretic separation of analytes; search and implementation of effective options for on-line and in-line preconcentration; a combination of a capillary electrophoresis system with a mass spectrometric detector for targeted and nontargeted metabolic profiling.