Abstract: In this paper, we consider the problem of constructing c-optimal designs for polynomial regression without an intercept. The special case of c = f '(z) (i.e., the vector of derivatives of the regression functions at some point z is selected as vector c) is considered. The analytical results available in the literature are briefly reviewed. An effective numerical method for finding f '(z)-optimal designs in cases in which an analytical solution cannot be constructed is proposed.