Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Research › peer-review
Given a fixed alignment scoring scheme, the bounded length (respectively, bounded total length) Smith-Waterman alignment problem on a pair of strings of lengths m, n, asks for the maximum alignment score across all substring pairs, such that the first substring's length (respectively, the sum of the two substrings' lengths) is above the given threshold w. The latter problem was introduced by Arslan and Eğecioğlu under the name “local alignment with length threshold”. They proposed a dynamic programming algorithm solving the problem in time O(mn2), and also an approximation algorithm running in time O(rmn), where r is a parameter controlling the accuracy of approximation. We show that both these problems can be solved exactly in time O(mn), assuming a rational scoring scheme; furthermore, this solution can be used to obtain an exact algorithm for the normalised bounded total length Smith-Waterman alignment problem, running in time O(mn log n). Our algorithms rely on the techniques of fast window-substring alignment and implicit unit-Monge matrix searching, developed previously by the author and others.
Original language | English |
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Title of host publication | 19th International Workshop on Algorithms in Bioinformatics, WABI 2019 |
Editors | Katharina T. Huber, Dan Gusfield |
Publisher | Schloss Dagstuhl- Leibniz-Zentrum fur Informatik GmbH, Dagstuhl Publishing |
ISBN (Electronic) | 9783959771238 |
DOIs | |
State | Published - Sep 2019 |
Event | 19th International Workshop on Algorithms in Bioinformatics, WABI 2019 - Niagara Falls, United States Duration: 8 Sep 2019 → 10 Sep 2019 |
Name | Leibniz International Proceedings in Informatics, LIPIcs |
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Volume | 143 |
ISSN (Print) | 1868-8969 |
Conference | 19th International Workshop on Algorithms in Bioinformatics, WABI 2019 |
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Country/Territory | United States |
City | Niagara Falls |
Period | 8/09/19 → 10/09/19 |
ID: 97181197