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@article{669eaf9795e84e74893f5424027c4cc6,
title = "Animal Models of Hemophilia B (A Review)",
abstract = "Abstract: Animal models play a key role in biomedical research, enabling the study of disease mechanisms and the assessment of novel therapies, with precise genetic models being especially critical for rare hereditary disorders like hemophilia B. These models allow for detailed investigation of pathogenesis, evaluation of drug efficacy, and the development of innovative treatments, including gene and cell therapy. This review summarizes currently avail- able hemophilia B laboratory animal models, including spontaneously mutated and genetically engineered strains.",
keywords = "F9 gene, FIX, animal models of hemophilia B, hemophilia B",
author = "Кандина, {Дарья Алексеевна} and Ахмаров, {Ильяс Идрисович} and Велижанина, {Мария Евгеньевна} and Кириллов, {Олег Андреевич} and Чиринскайте, {Ангелина Валерьевна} and Луганская, {Полина Сергеевна} and Сопова, {Юлия Викторовна} and Леонова, {Елена Ивановна}",
year = "2025",
month = aug,
day = "19",
doi = "10.1134/S1990519X25600498",
language = "English",
volume = "19",
pages = "S96–S103",
journal = "Cell and Tissue Biology",
issn = "1990-519X",
publisher = "МАИК {"}Наука/Интерпериодика{"}",
number = "Suppl 1",

}

RIS

TY - JOUR

T1 - Animal Models of Hemophilia B (A Review)

AU - Кандина, Дарья Алексеевна

AU - Ахмаров, Ильяс Идрисович

AU - Велижанина, Мария Евгеньевна

AU - Кириллов, Олег Андреевич

AU - Чиринскайте, Ангелина Валерьевна

AU - Луганская, Полина Сергеевна

AU - Сопова, Юлия Викторовна

AU - Леонова, Елена Ивановна

PY - 2025/8/19

Y1 - 2025/8/19

N2 - Abstract: Animal models play a key role in biomedical research, enabling the study of disease mechanisms and the assessment of novel therapies, with precise genetic models being especially critical for rare hereditary disorders like hemophilia B. These models allow for detailed investigation of pathogenesis, evaluation of drug efficacy, and the development of innovative treatments, including gene and cell therapy. This review summarizes currently avail- able hemophilia B laboratory animal models, including spontaneously mutated and genetically engineered strains.

AB - Abstract: Animal models play a key role in biomedical research, enabling the study of disease mechanisms and the assessment of novel therapies, with precise genetic models being especially critical for rare hereditary disorders like hemophilia B. These models allow for detailed investigation of pathogenesis, evaluation of drug efficacy, and the development of innovative treatments, including gene and cell therapy. This review summarizes currently avail- able hemophilia B laboratory animal models, including spontaneously mutated and genetically engineered strains.

KW - F9 gene

KW - FIX

KW - animal models of hemophilia B

KW - hemophilia B

UR - https://www.mendeley.com/catalogue/e894b604-d48b-3131-9f73-eb57447bc9ba/

U2 - 10.1134/S1990519X25600498

DO - 10.1134/S1990519X25600498

M3 - Article

VL - 19

SP - S96–S103

JO - Cell and Tissue Biology

JF - Cell and Tissue Biology

SN - 1990-519X

IS - Suppl 1

ER -

ID: 140460486