TY - JOUR

T1 - Amyloid Precursor Protein as a Functional Hub of Synaptic Plasticity

AU - Сабурова, Екатерина Андреевна

AU - Саранцева, Светлана Владимировна

AU - Кривой, Игорь Ильич

PY - 2026/8/1

Y1 - 2026/8/1

N2 - —Interest in the amyloid precursor protein (APP) initially arose in the study of Alzheimer’s disease, since amyloid β (Aβ), a product of proteolytic processing of APP, was considered key in the pathogenesis of this disease. However, subsequent more detailed and in-depth studies significantly expanded understanding of the functional spectrum of APP family proteins and demonstrated their involvement in many important physiological processes. Currently, APP is considered as a regulatory hub that forms a network of interacting proteins involved in synaptic and neural plasticity, which are a fundamental basis for learning, memory, cognition and behavior. This review analyzes and summarizes insights into the physiological role of the APP and its proteolytic fragments. Problems and the most promising areas for further development are also discussed.

AB - —Interest in the amyloid precursor protein (APP) initially arose in the study of Alzheimer’s disease, since amyloid β (Aβ), a product of proteolytic processing of APP, was considered key in the pathogenesis of this disease. However, subsequent more detailed and in-depth studies significantly expanded understanding of the functional spectrum of APP family proteins and demonstrated their involvement in many important physiological processes. Currently, APP is considered as a regulatory hub that forms a network of interacting proteins involved in synaptic and neural plasticity, which are a fundamental basis for learning, memory, cognition and behavior. This review analyzes and summarizes insights into the physiological role of the APP and its proteolytic fragments. Problems and the most promising areas for further development are also discussed.

UR - https://www.mendeley.com/catalogue/8e05dafe-6cbb-3814-bc53-c3120ab9386f/

U2 - 10.1134/s0022093026040174

DO - 10.1134/s0022093026040174

M3 - Article

VL - 62

SP - 1300

EP - 1321

JO - Journal of Evolutionary Biochemistry and Physiology

JF - Journal of Evolutionary Biochemistry and Physiology

SN - 0022-0930

IS - 4

ER -