Standard
A Two-Step Synthesis of Unprotected 3-Aminoindoles via Post Functionalization with Nitrostyrene : This article belongs to the Special Issue Synthesis of Bioactive Compounds. / Аксенов, Николай; Куренков, Игорь; Арутюнов, Николай; Малюга, Владимир; Аксенов, Дмитрий ; Момотова, Дарья; Зацепилина, Анна; Чуканова, Елизавета Александровна; Леонтьев, Александр; Аксенов, Александр.
In:
Molecules, Vol. 28, No. 9, 3657, 23.04.2023.
Research output: Contribution to journal › Article › peer-review
Harvard
Аксенов, Н, Куренков, И, Арутюнов, Н, Малюга, В, Аксенов, Д, Момотова, Д, Зацепилина, А
, Чуканова, ЕА, Леонтьев, А & Аксенов, А 2023, '
A Two-Step Synthesis of Unprotected 3-Aminoindoles via Post Functionalization with Nitrostyrene: This article belongs to the Special Issue Synthesis of Bioactive Compounds',
Molecules, vol. 28, no. 9, 3657.
https://doi.org/10.3390/molecules28093657APA
Аксенов, Н., Куренков, И., Арутюнов, Н., Малюга, В., Аксенов, Д., Момотова, Д., Зацепилина, А.
, Чуканова, Е. А., Леонтьев, А., & Аксенов, А. (2023).
A Two-Step Synthesis of Unprotected 3-Aminoindoles via Post Functionalization with Nitrostyrene: This article belongs to the Special Issue Synthesis of Bioactive Compounds.
Molecules,
28(9), [3657].
https://doi.org/10.3390/molecules28093657Vancouver
Author
Аксенов, Николай ; Куренков, Игорь ; Арутюнов, Николай ; Малюга, Владимир ; Аксенов, Дмитрий ; Момотова, Дарья ; Зацепилина, Анна
; Чуканова, Елизавета Александровна ; Леонтьев, Александр ; Аксенов, Александр. /
A Two-Step Synthesis of Unprotected 3-Aminoindoles via Post Functionalization with Nitrostyrene : This article belongs to the Special Issue Synthesis of Bioactive Compounds. In:
Molecules. 2023 ; Vol. 28, No. 9.
BibTeX
@article{956b82e0d5df4d8cabbfc214bd7439ae,
title = "A Two-Step Synthesis of Unprotected 3-Aminoindoles via Post Functionalization with Nitrostyrene: This article belongs to the Special Issue Synthesis of Bioactive Compounds",
abstract = "A novel, low-cost method for the preparation of not easily accessible free 3-aminoindoles has been developed. This approach is based on a well-established reaction between indoles and nitrostyrene in the presence of phosphorous acid, which results in the formation of 4'-phenyl-4'H-spiro[indole-3,5'-isoxazoles]. The latter could be transformed to corresponding aminated indoles by reaction with hydrazine hydrate in good or excellent yields upon microwave-assisted heating.",
keywords = "C3-amination of indoles, cascade transformations, phenylacetonitrile extrusion",
author = "Николай Аксенов and Игорь Куренков and Николай Арутюнов and Владимир Малюга and Дмитрий Аксенов and Дарья Момотова and Анна Зацепилина and Чуканова, {Елизавета Александровна} and Александр Леонтьев and Александр Аксенов",
year = "2023",
month = apr,
day = "23",
doi = "10.3390/molecules28093657",
language = "English",
volume = "28",
journal = "Molecules",
issn = "1420-3049",
publisher = "MDPI AG",
number = "9",
}
RIS
TY - JOUR
T1 - A Two-Step Synthesis of Unprotected 3-Aminoindoles via Post Functionalization with Nitrostyrene
T2 - This article belongs to the Special Issue Synthesis of Bioactive Compounds
AU - Аксенов, Николай
AU - Куренков, Игорь
AU - Арутюнов, Николай
AU - Малюга, Владимир
AU - Аксенов, Дмитрий
AU - Момотова, Дарья
AU - Зацепилина, Анна
AU - Чуканова, Елизавета Александровна
AU - Леонтьев, Александр
AU - Аксенов, Александр
PY - 2023/4/23
Y1 - 2023/4/23
N2 - A novel, low-cost method for the preparation of not easily accessible free 3-aminoindoles has been developed. This approach is based on a well-established reaction between indoles and nitrostyrene in the presence of phosphorous acid, which results in the formation of 4'-phenyl-4'H-spiro[indole-3,5'-isoxazoles]. The latter could be transformed to corresponding aminated indoles by reaction with hydrazine hydrate in good or excellent yields upon microwave-assisted heating.
AB - A novel, low-cost method for the preparation of not easily accessible free 3-aminoindoles has been developed. This approach is based on a well-established reaction between indoles and nitrostyrene in the presence of phosphorous acid, which results in the formation of 4'-phenyl-4'H-spiro[indole-3,5'-isoxazoles]. The latter could be transformed to corresponding aminated indoles by reaction with hydrazine hydrate in good or excellent yields upon microwave-assisted heating.
KW - C3-amination of indoles
KW - cascade transformations
KW - phenylacetonitrile extrusion
UR - https://www.mendeley.com/catalogue/69066d5f-8ddc-3d9d-bb06-fc95a45457d3/
U2 - 10.3390/molecules28093657
DO - 10.3390/molecules28093657
M3 - Article
C2 - 37175067
VL - 28
JO - Molecules
JF - Molecules
SN - 1420-3049
IS - 9
M1 - 3657
ER -
