Research output: Contribution to journal › Article › peer-review
A SIMPLE ROUTE TO SIDE-CHAIN FLUORINATED Β-LACTAMS FROM RING-FLUORINATED AZIRIDINES. / Konev, A.S.; Novikov, M.S.; Khlebnikov, A.F.; Tehrani, K.A.
In: Journal of Fluorine Chemistry, No. 2, 2007, p. 114-119.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - A SIMPLE ROUTE TO SIDE-CHAIN FLUORINATED Β-LACTAMS FROM RING-FLUORINATED AZIRIDINES
AU - Konev, A.S.
AU - Novikov, M.S.
AU - Khlebnikov, A.F.
AU - Tehrani, K.A.
PY - 2007
Y1 - 2007
N2 - β-Lactams bearing a Ph2CF substituent at the C(4)-atom were synthesized from N-alkyl-2-fluoro-3,3-diphenylaziridines. The transformation was realized using SbF3-mediated isomerization of the monofluoroaziridines to fluorinated aldimines, followed by Staudinger reaction with ketenes. It was shown that this reaction sequence can be performed as a one-pot procedure. © 2006 Elsevier B.V. All rights reserved.
AB - β-Lactams bearing a Ph2CF substituent at the C(4)-atom were synthesized from N-alkyl-2-fluoro-3,3-diphenylaziridines. The transformation was realized using SbF3-mediated isomerization of the monofluoroaziridines to fluorinated aldimines, followed by Staudinger reaction with ketenes. It was shown that this reaction sequence can be performed as a one-pot procedure. © 2006 Elsevier B.V. All rights reserved.
M3 - Article
SP - 114
EP - 119
JO - Journal of Fluorine Chemistry
JF - Journal of Fluorine Chemistry
SN - 0022-1139
IS - 2
ER -
ID: 5009826