Research output: Contribution to journal › Article › peer-review
α-Carbamoyl phosphonates are useful reagents for the Horner-Wadsworth-Emmons olefination of aldehydes en route to medicinally relevant polysubstituted acrylamides. A new synthetic approach to these reagents has been developed. The methodology relies on the microwave-promoted Wolff rearrangement of α-acyl-α-diazophosphonates with trapping of the ketene intermediate in situ with various amines.
Original language | English |
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Pages (from-to) | 1487-1490 |
Number of pages | 4 |
Journal | Synlett |
Volume | 31 |
Issue number | 15 |
Early online date | 20 Jun 2020 |
DOIs | |
State | Published - 16 Sep 2020 |
ID: 61393314