Research output: Contribution to journal › Article › peer-review
A comprehensive study of biocompatibility of detonation nanodiamonds. / Berdichevskiy, Gregory M.; Vasina, Lubov V.; Ageev, Sergei V.; Meshcheriakov, Anatolii A.; Galkin, Mikhail A.; Ishmukhametov, Robert R.; Nashchekin, Alexei V.; Kirilenko, Demid A.; Petrov, Andrey V.; Martynova, Sofia D.; Semenov, Konstantin N.; Sharoyko, Vladimir V.
In: Journal of Molecular Liquids, Vol. 332, 115763, 15.06.2021.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - A comprehensive study of biocompatibility of detonation nanodiamonds
AU - Berdichevskiy, Gregory M.
AU - Vasina, Lubov V.
AU - Ageev, Sergei V.
AU - Meshcheriakov, Anatolii A.
AU - Galkin, Mikhail A.
AU - Ishmukhametov, Robert R.
AU - Nashchekin, Alexei V.
AU - Kirilenko, Demid A.
AU - Petrov, Andrey V.
AU - Martynova, Sofia D.
AU - Semenov, Konstantin N.
AU - Sharoyko, Vladimir V.
N1 - Publisher Copyright: © 2021 Copyright: Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/6/15
Y1 - 2021/6/15
N2 - The article describes a complex study of detonation nanodiamonds (DND) aqueous dispersions. In this research, DND sample was characterised by means of IR, NMR spectroscopy, TEM, thermogravimetric analysis, size distribution, and ζ-potentials. It was shown that DND sample includes several surface groups, mainly hydroxylic, carboxylic, and carbonyl ones. Dynamic light scattering results revealed that in the concentration range C = 0.002–0.3 wt%, DND nanoparticles size is equal to 55 ± 5 nm. It was demonstrated that DND possessed weak antiradical activity, had an inhibitory effect on F1F0-ATPase activity, almost did not affect platelet aggregation, formed a stronger complex with human serum albumin (HSA) in subdomain IB (digitoxin, Kb = 20.0 ± 2.4 l·g−1) and a less strong complex in subdomain IIA (warfarin, Kb = 3.7 ± 0.1 l·g−1), inhibited the esterase activity of HSA, DND dispersions (C = 0.0012–0.15 wt%) revealed genotoxic effect towards PBMCs, did not affect cellular proliferation in the experiment with HEK293 cell line, did not reveal cytotoxic effect up to 0.01 wt%. Using DFT and MD approaches allowed us to perform a simulation of interaction between DND nanoparticle and water molecules.
AB - The article describes a complex study of detonation nanodiamonds (DND) aqueous dispersions. In this research, DND sample was characterised by means of IR, NMR spectroscopy, TEM, thermogravimetric analysis, size distribution, and ζ-potentials. It was shown that DND sample includes several surface groups, mainly hydroxylic, carboxylic, and carbonyl ones. Dynamic light scattering results revealed that in the concentration range C = 0.002–0.3 wt%, DND nanoparticles size is equal to 55 ± 5 nm. It was demonstrated that DND possessed weak antiradical activity, had an inhibitory effect on F1F0-ATPase activity, almost did not affect platelet aggregation, formed a stronger complex with human serum albumin (HSA) in subdomain IB (digitoxin, Kb = 20.0 ± 2.4 l·g−1) and a less strong complex in subdomain IIA (warfarin, Kb = 3.7 ± 0.1 l·g−1), inhibited the esterase activity of HSA, DND dispersions (C = 0.0012–0.15 wt%) revealed genotoxic effect towards PBMCs, did not affect cellular proliferation in the experiment with HEK293 cell line, did not reveal cytotoxic effect up to 0.01 wt%. Using DFT and MD approaches allowed us to perform a simulation of interaction between DND nanoparticle and water molecules.
KW - Detonation nanodiamonds
KW - DPPH
KW - Genotoxicity
KW - HSA
KW - Molecular dynamics
KW - Platelets
KW - NUCLEAR-MAGNETIC-RESONANCE
KW - FLUORESCENT NANODIAMONDS
KW - DIAMOND-LIKE CARBON
KW - NANOPARTICLES
KW - POWDERS
KW - SPECTROSCOPY
KW - FTIR
KW - SURFACE
KW - CHEMISTRY
KW - COATINGS
UR - http://www.scopus.com/inward/record.url?scp=85102266989&partnerID=8YFLogxK
U2 - 10.1016/j.molliq.2021.115763
DO - 10.1016/j.molliq.2021.115763
M3 - Article
AN - SCOPUS:85102266989
VL - 332
JO - Journal of Molecular Liquids
JF - Journal of Molecular Liquids
SN - 0167-7322
M1 - 115763
ER -
ID: 77056072