Research output: Contribution to journal › Article › peer-review
A chemiluminescence method for screening of fluoroquinolones in milk samples based on a multi-pumping flow system. / Vakh, Christina ; Pochivalov, Aleksei ; Koronkiewicz, Stanislawa; Postnov, Viktor ; Bulatov, Andrey .
In: Food Chemistry, Vol. 270, 01.01.2019, p. 10-16.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - A chemiluminescence method for screening of fluoroquinolones in milk samples based on a multi-pumping flow system
AU - Vakh, Christina
AU - Pochivalov, Aleksei
AU - Koronkiewicz, Stanislawa
AU - Postnov, Viktor
AU - Bulatov, Andrey
PY - 2019/1/1
Y1 - 2019/1/1
N2 - An automated and miniaturized chemiluminescence method for screening of fluoroquinolones in milk samples was proposed. The method was based on magnetic dispersive micro-solid phase extraction of analytes followed by the chemiluminescence determination of the total fluoroquinolones content using a multi-pumping flow system. In the developed method, Zr-Fe-C magnetic nanoparticles were used as an efficient sorbent for separation of fluoroquinolones from sample matrix. The chemiluminescence intensity obtained for Ce 4+-SO 3 2−-Tb 3+ chemiluminescence system was greatly increased in the presence of the analytes. Under the optimal conditions, the detector response for fluoroquinolones was linear in the concentration ranges from 5·10 −9 to 1·10 −6 mol L −1 with respect to fleroxacin. The limit of detection, calculated from a blank test based on 3σ was 2·10 −9 mol L −1 with respect to fleroxacin. The presented method demonstrated to be a good tool for available and cost-effective point-of-need screening fluoroquinolones in milk samples.
AB - An automated and miniaturized chemiluminescence method for screening of fluoroquinolones in milk samples was proposed. The method was based on magnetic dispersive micro-solid phase extraction of analytes followed by the chemiluminescence determination of the total fluoroquinolones content using a multi-pumping flow system. In the developed method, Zr-Fe-C magnetic nanoparticles were used as an efficient sorbent for separation of fluoroquinolones from sample matrix. The chemiluminescence intensity obtained for Ce 4+-SO 3 2−-Tb 3+ chemiluminescence system was greatly increased in the presence of the analytes. Under the optimal conditions, the detector response for fluoroquinolones was linear in the concentration ranges from 5·10 −9 to 1·10 −6 mol L −1 with respect to fleroxacin. The limit of detection, calculated from a blank test based on 3σ was 2·10 −9 mol L −1 with respect to fleroxacin. The presented method demonstrated to be a good tool for available and cost-effective point-of-need screening fluoroquinolones in milk samples.
KW - Ammonium cerium (IV) nitrate (PubChem CID: 9869224)
KW - Ammonium hydroxide (PubChem CID: 14923)
KW - Chemiluminescence
KW - Direct-injection detector
KW - Fleroxacin (PubChem CID: 3357)
KW - Fluoroquinolones
KW - Lomefloxacin (PubChem CID: 3948)
KW - Magnetic dispersive micro-solid phase extraction
KW - Methanol (PubChem CID: 887)
KW - Milk
KW - Multi-pumping flow system
KW - Norfloxacin (PubChem CID: 4539)
KW - Ofloxacin (PubChem CID: 4583)
KW - Screening
KW - Sodium hydroxide (PubChem CID: 14798)
KW - Sodium sulfite (PubChem CID: 24437)
KW - Terbium chloride hexahydrate (PubChem CID: 203091)
KW - HPLC-FLD DETERMINATION
KW - SULFONAMIDE
KW - OFLOXACIN
KW - SENSITIZED CHEMILUMINESCENCE
KW - SOLID-PHASE EXTRACTION
KW - ASSAY
KW - MEAT
KW - LIQUID-CHROMATOGRAPHY
KW - RESIDUES
UR - http://www.scopus.com/inward/record.url?scp=85049787641&partnerID=8YFLogxK
U2 - 10.1016/j.foodchem.2018.07.073
DO - 10.1016/j.foodchem.2018.07.073
M3 - Article
VL - 270
SP - 10
EP - 16
JO - Food Chemistry
JF - Food Chemistry
SN - 0308-8146
ER -
ID: 33861461