A novel 12-step procedure was developed for preparing methyl 14-isocyano-3-methyltetradecanoate. “2+1B” tricarbonyl complexes [99mTc(CO)3(N^N)CN(CH2)11CH(CH3)CH2COOMe]+, where N^N = 2,2'-bipyridine
(bipy) or 1,10-phenanthroline (phen), were prepared by the reaction of [99mTc(CO)3(N^N)(H2O,EtOH)]+ with
methyl 14-isocyano-3-methyltetradecanoate in aqueous ethanol. The formation of technetium-99m complexes
was confi rmed by HPLC, and the partition coeffi cient (n-octanol/water) of these complexes was measured.
Original languageEnglish
Pages (from-to)521–529
JournalRadiochemistry
Volume66
Issue number4
DOIs
StatePublished - 1 Aug 2024

ID: 124716501