Condensation of amidoximes 1 with isatoic anhydrides 2 or esters 3 in NaOH/DMSO medium afforded to substituted 1,2,4-oxadiazolyl anilines. The compounds synthesized can exhibit luminescence, the presence and efficiency of which depends on the position of the amino group in these aminophenyl 1,2,4-oxadiazol derivatives. The best luminophores are 2-(orthoaminophenyl) 1,2,4-oxadiazoles. More than 20 examples of the new organic luminophores were synthesized and studied. The effect of the luminophore structure on the emission band and on the quantum yield indicates that a luminescent scaffold has been obtained.