Research output: Contribution to journal › Review article › peer-review
18F-FDG and Other Labeled Glucose Derivatives for Use in Radionuclide Diagnosis of Oncological Diseases (Review). / Petriev, V.M.; Tishchenko, V.K.; Krasikova, R. N.
In: Pharmaceutical Chemistry Journal, Vol. 50, No. 4, 08.2016, p. 209-220.Research output: Contribution to journal › Review article › peer-review
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TY - JOUR
T1 - 18F-FDG and Other Labeled Glucose Derivatives for Use in Radionuclide Diagnosis of Oncological Diseases (Review)
AU - Petriev, V.M.
AU - Tishchenko, V.K.
AU - Krasikova, R. N.
PY - 2016/8
Y1 - 2016/8
N2 - This review addresses progress in the radionuclide diagnosis of oncological diseases using radiopharmaceutical preparations (RPP) based on labeled glucose derivatives. Most attention is paid to 2-[F-18]fluoro-2-deoxy-D-glucose (F-18-FDG), a glucose analog labeled with fluorine-18 (T (1/2) = 110 min) and the only radiotracer for glycolysis, which is used in 90% of clinical studies using positron emission tomography (PET). We describe approaches to the synthesis of F-18-FDG and state-of-the-art automated technologies allowing tens of clinical doses of RPP for PET investigations of patients to be prepared. The main areas of use of PET with F-18-FDG in the diagnosis of various tumors are discussed, as is the potential for using glucose derivatives with other radionuclides (Ga-68, I-123, Tc-99m, Re-188) as tracers for use in PET and SPECT diagnosis.
AB - This review addresses progress in the radionuclide diagnosis of oncological diseases using radiopharmaceutical preparations (RPP) based on labeled glucose derivatives. Most attention is paid to 2-[F-18]fluoro-2-deoxy-D-glucose (F-18-FDG), a glucose analog labeled with fluorine-18 (T (1/2) = 110 min) and the only radiotracer for glycolysis, which is used in 90% of clinical studies using positron emission tomography (PET). We describe approaches to the synthesis of F-18-FDG and state-of-the-art automated technologies allowing tens of clinical doses of RPP for PET investigations of patients to be prepared. The main areas of use of PET with F-18-FDG in the diagnosis of various tumors are discussed, as is the potential for using glucose derivatives with other radionuclides (Ga-68, I-123, Tc-99m, Re-188) as tracers for use in PET and SPECT diagnosis.
KW - 2-[F-18]Fluoro-2-deoxy-D-glucose
KW - F-18-FDG
KW - radiopharmaceutical preparations
KW - radiotracers
KW - oncological diagnosis
KW - positron emission tomography
KW - PET
KW - single-photon emission computed tomography
KW - SPECT
KW - planar scintigraphy
KW - PS
KW - labeled glucose derivatives
KW - POSITRON-EMISSION-TOMOGRAPHY
KW - STANDARDIZED UPTAKE VALUE
KW - DIFFERENTIATED THYROID-CARCINOMA
KW - RECURRENT COLORECTAL-CANCER
KW - GERM-CELL TUMORS
KW - FDG-PET
KW - BIOLOGICAL EVALUATION
KW - DEOXYGLUCOSE DERIVATIVES
KW - FLUORODEOXYGLUCOSE PET
KW - BREAST-CANCER
U2 - 10.1007/s11094-016-1425-y
DO - 10.1007/s11094-016-1425-y
M3 - Обзорная статья
VL - 50
SP - 209
EP - 220
JO - Pharmaceutical Chemistry Journal
JF - Pharmaceutical Chemistry Journal
SN - 0091-150X
IS - 4
ER -
ID: 9431353